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Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

BACKGROUND: Although perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcino...

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Autores principales: Kim, Ha Eun, Park, Seong Yong, Kim, Hyunki, Kim, Dae Joon, Kim, Sun Ill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107023/
https://www.ncbi.nlm.nih.gov/pubmed/33811752
http://dx.doi.org/10.1111/1759-7714.13960
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author Kim, Ha Eun
Park, Seong Yong
Kim, Hyunki
Kim, Dae Joon
Kim, Sun Ill
author_facet Kim, Ha Eun
Park, Seong Yong
Kim, Hyunki
Kim, Dae Joon
Kim, Sun Ill
author_sort Kim, Ha Eun
collection PubMed
description BACKGROUND: Although perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcinoma. METHODS: We retrospectively reviewed the medical records of 316 patients who underwent esophagectomy and lymph node dissection for esophageal squamous cell carcinoma between 2007 and 2016. RESULTS: Overall, 287 men (mean age: 62.73 ± 7.97 years) were included in the study. The median follow‐up period was 35.97 ± 30.99 months, perineural invasion was confirmed in 25 patients, and three‐year overall and disease‐free survival were significantly lower in the perineural invasion group than in the no‐perineural invasion group (75.9% vs. 40.0%, p < 0.001; 70.3% vs. 21.6%, p < 0.001). Cumulative incidences of locoregional recurrence and distant metastasis over three years were higher in the perineural invasion group (13.8% vs. 9.6%, p = 0.009 and 52.8% vs. 14.6%, p < 0.001). On performing multivariable analysis, perineural invasion, pathological stage, incomplete resection, and neoadjuvant therapy were adverse risk factors for disease‐free survival. The concordance index increased when perineural invasion was included in the model (0.712 vs. 0.723). On subgroup analysis, perineural invasion demonstrated a prognostic value in node‐negative patients (79.4% vs. 35.7%, p = 0.012). CONCLUSIONS: Perineural invasion was found to be an adverse risk factor for disease‐free survival in surgically treated patients with esophageal squamous cell carcinoma. Close observation and individualized adjuvant therapy may be helpful for patients with perineural invasion.
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spelling pubmed-81070232021-05-10 Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma Kim, Ha Eun Park, Seong Yong Kim, Hyunki Kim, Dae Joon Kim, Sun Ill Thorac Cancer Original Articles BACKGROUND: Although perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcinoma. METHODS: We retrospectively reviewed the medical records of 316 patients who underwent esophagectomy and lymph node dissection for esophageal squamous cell carcinoma between 2007 and 2016. RESULTS: Overall, 287 men (mean age: 62.73 ± 7.97 years) were included in the study. The median follow‐up period was 35.97 ± 30.99 months, perineural invasion was confirmed in 25 patients, and three‐year overall and disease‐free survival were significantly lower in the perineural invasion group than in the no‐perineural invasion group (75.9% vs. 40.0%, p < 0.001; 70.3% vs. 21.6%, p < 0.001). Cumulative incidences of locoregional recurrence and distant metastasis over three years were higher in the perineural invasion group (13.8% vs. 9.6%, p = 0.009 and 52.8% vs. 14.6%, p < 0.001). On performing multivariable analysis, perineural invasion, pathological stage, incomplete resection, and neoadjuvant therapy were adverse risk factors for disease‐free survival. The concordance index increased when perineural invasion was included in the model (0.712 vs. 0.723). On subgroup analysis, perineural invasion demonstrated a prognostic value in node‐negative patients (79.4% vs. 35.7%, p = 0.012). CONCLUSIONS: Perineural invasion was found to be an adverse risk factor for disease‐free survival in surgically treated patients with esophageal squamous cell carcinoma. Close observation and individualized adjuvant therapy may be helpful for patients with perineural invasion. John Wiley & Sons Australia, Ltd 2021-04-03 2021-05 /pmc/articles/PMC8107023/ /pubmed/33811752 http://dx.doi.org/10.1111/1759-7714.13960 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Kim, Ha Eun
Park, Seong Yong
Kim, Hyunki
Kim, Dae Joon
Kim, Sun Ill
Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title_full Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title_fullStr Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title_full_unstemmed Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title_short Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
title_sort prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107023/
https://www.ncbi.nlm.nih.gov/pubmed/33811752
http://dx.doi.org/10.1111/1759-7714.13960
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