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Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis

BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early...

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Autores principales: Sun, Yungang, Zhang, Qiang, Wang, Zhao, Shao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107027/
https://www.ncbi.nlm.nih.gov/pubmed/33793088
http://dx.doi.org/10.1111/1759-7714.13955
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author Sun, Yungang
Zhang, Qiang
Wang, Zhao
Shao, Feng
author_facet Sun, Yungang
Zhang, Qiang
Wang, Zhao
Shao, Feng
author_sort Sun, Yungang
collection PubMed
description BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early‐stage cases. METHODS: We retrospectively analyzed 416 patients with pathological stage IA NSCLC from February 2016 to November 2019. The patients were divided into a group with ILN dissection (ILN(D+) group) and a group without ILN dissection (ILN(D‐) group). DFS was compared using the Kaplan–Meier method and compared statistically using the log‐rank test before and after propensity score matching (PSM). Subgroup analysis of DFS stratified based on tumor size was also calculated. RESULTS: Both before and after PSM, the four‐year DFS of the ILN(D+) group was greatly increased compared to that of ILN(D‐) group (90.1% vs. 79.7%, p = 0.003; 95.5% vs. 80.6%, p = 0.003, respectively) and multivariable cox regression analysis revealed ILN dissection was an independent factor favoring DFS in stage IA NSCLC (p = 0.016 and p = 0.015, respectively). Subgroup analysis revealed the four‐year DFS was comparable between the ILN (D+) and ILN(D‐) groups with regard to tumor size ≤1.5 cm (90.6% vs. 92.7%, p = 0.715). However, the ILN (D+) group was found to have a better oncological outcome compared with the ILN(D‐) group with regard to tumor size >1.5 cm (90.0% vs. 73.8%, p = 0.003). CONCLUSIONS: The prognostic impact of ILN dissection on patients with stage IA NSCLC appears to be significantly influenced by tumor size, and this should be taken into account when choosing the most appropriate therapeutic modality.
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spelling pubmed-81070272021-05-10 Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis Sun, Yungang Zhang, Qiang Wang, Zhao Shao, Feng Thorac Cancer Original Articles BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early‐stage cases. METHODS: We retrospectively analyzed 416 patients with pathological stage IA NSCLC from February 2016 to November 2019. The patients were divided into a group with ILN dissection (ILN(D+) group) and a group without ILN dissection (ILN(D‐) group). DFS was compared using the Kaplan–Meier method and compared statistically using the log‐rank test before and after propensity score matching (PSM). Subgroup analysis of DFS stratified based on tumor size was also calculated. RESULTS: Both before and after PSM, the four‐year DFS of the ILN(D+) group was greatly increased compared to that of ILN(D‐) group (90.1% vs. 79.7%, p = 0.003; 95.5% vs. 80.6%, p = 0.003, respectively) and multivariable cox regression analysis revealed ILN dissection was an independent factor favoring DFS in stage IA NSCLC (p = 0.016 and p = 0.015, respectively). Subgroup analysis revealed the four‐year DFS was comparable between the ILN (D+) and ILN(D‐) groups with regard to tumor size ≤1.5 cm (90.6% vs. 92.7%, p = 0.715). However, the ILN (D+) group was found to have a better oncological outcome compared with the ILN(D‐) group with regard to tumor size >1.5 cm (90.0% vs. 73.8%, p = 0.003). CONCLUSIONS: The prognostic impact of ILN dissection on patients with stage IA NSCLC appears to be significantly influenced by tumor size, and this should be taken into account when choosing the most appropriate therapeutic modality. John Wiley & Sons Australia, Ltd 2021-04-01 2021-05 /pmc/articles/PMC8107027/ /pubmed/33793088 http://dx.doi.org/10.1111/1759-7714.13955 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Sun, Yungang
Zhang, Qiang
Wang, Zhao
Shao, Feng
Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title_full Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title_fullStr Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title_full_unstemmed Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title_short Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
title_sort clinical significance of intrapulmonary lymph node dissection in pathological stage ia non‐small cell lung cancer: a propensity score matching analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107027/
https://www.ncbi.nlm.nih.gov/pubmed/33793088
http://dx.doi.org/10.1111/1759-7714.13955
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