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Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis
BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107027/ https://www.ncbi.nlm.nih.gov/pubmed/33793088 http://dx.doi.org/10.1111/1759-7714.13955 |
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author | Sun, Yungang Zhang, Qiang Wang, Zhao Shao, Feng |
author_facet | Sun, Yungang Zhang, Qiang Wang, Zhao Shao, Feng |
author_sort | Sun, Yungang |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early‐stage cases. METHODS: We retrospectively analyzed 416 patients with pathological stage IA NSCLC from February 2016 to November 2019. The patients were divided into a group with ILN dissection (ILN(D+) group) and a group without ILN dissection (ILN(D‐) group). DFS was compared using the Kaplan–Meier method and compared statistically using the log‐rank test before and after propensity score matching (PSM). Subgroup analysis of DFS stratified based on tumor size was also calculated. RESULTS: Both before and after PSM, the four‐year DFS of the ILN(D+) group was greatly increased compared to that of ILN(D‐) group (90.1% vs. 79.7%, p = 0.003; 95.5% vs. 80.6%, p = 0.003, respectively) and multivariable cox regression analysis revealed ILN dissection was an independent factor favoring DFS in stage IA NSCLC (p = 0.016 and p = 0.015, respectively). Subgroup analysis revealed the four‐year DFS was comparable between the ILN (D+) and ILN(D‐) groups with regard to tumor size ≤1.5 cm (90.6% vs. 92.7%, p = 0.715). However, the ILN (D+) group was found to have a better oncological outcome compared with the ILN(D‐) group with regard to tumor size >1.5 cm (90.0% vs. 73.8%, p = 0.003). CONCLUSIONS: The prognostic impact of ILN dissection on patients with stage IA NSCLC appears to be significantly influenced by tumor size, and this should be taken into account when choosing the most appropriate therapeutic modality. |
format | Online Article Text |
id | pubmed-8107027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81070272021-05-10 Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis Sun, Yungang Zhang, Qiang Wang, Zhao Shao, Feng Thorac Cancer Original Articles BACKGROUND: This study aimed to investigate the prognostic impact of intrapulmonary lymph node (ILN, stations 13–14) dissection on disease‐free survival (DFS) in stage IA non‐small cell lung cancer (NSCLC) patients in order to facilitate a more suitable determination of surgical strategies for early‐stage cases. METHODS: We retrospectively analyzed 416 patients with pathological stage IA NSCLC from February 2016 to November 2019. The patients were divided into a group with ILN dissection (ILN(D+) group) and a group without ILN dissection (ILN(D‐) group). DFS was compared using the Kaplan–Meier method and compared statistically using the log‐rank test before and after propensity score matching (PSM). Subgroup analysis of DFS stratified based on tumor size was also calculated. RESULTS: Both before and after PSM, the four‐year DFS of the ILN(D+) group was greatly increased compared to that of ILN(D‐) group (90.1% vs. 79.7%, p = 0.003; 95.5% vs. 80.6%, p = 0.003, respectively) and multivariable cox regression analysis revealed ILN dissection was an independent factor favoring DFS in stage IA NSCLC (p = 0.016 and p = 0.015, respectively). Subgroup analysis revealed the four‐year DFS was comparable between the ILN (D+) and ILN(D‐) groups with regard to tumor size ≤1.5 cm (90.6% vs. 92.7%, p = 0.715). However, the ILN (D+) group was found to have a better oncological outcome compared with the ILN(D‐) group with regard to tumor size >1.5 cm (90.0% vs. 73.8%, p = 0.003). CONCLUSIONS: The prognostic impact of ILN dissection on patients with stage IA NSCLC appears to be significantly influenced by tumor size, and this should be taken into account when choosing the most appropriate therapeutic modality. John Wiley & Sons Australia, Ltd 2021-04-01 2021-05 /pmc/articles/PMC8107027/ /pubmed/33793088 http://dx.doi.org/10.1111/1759-7714.13955 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Sun, Yungang Zhang, Qiang Wang, Zhao Shao, Feng Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title | Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title_full | Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title_fullStr | Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title_full_unstemmed | Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title_short | Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non‐small cell lung cancer: A propensity score matching analysis |
title_sort | clinical significance of intrapulmonary lymph node dissection in pathological stage ia non‐small cell lung cancer: a propensity score matching analysis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107027/ https://www.ncbi.nlm.nih.gov/pubmed/33793088 http://dx.doi.org/10.1111/1759-7714.13955 |
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