Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report

A 62‐year‐old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bron...

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Detalles Bibliográficos
Autores principales: Morishita, Momoko, Suzuki, Manabu, Watanabe, Hiromu, Morita, Chie, Ishida, Akane, Hashimoto, Masao, Naka, Go, Takeda, Yuichiro, Hojo, Masayuki, Sugiyama, Haruhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107029/
https://www.ncbi.nlm.nih.gov/pubmed/33755322
http://dx.doi.org/10.1111/1759-7714.13946
Descripción
Sumario:A 62‐year‐old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bronchoscopy was performed as metastasis was suspected; however, this was not detected on lung biopsy with forceps. Transbronchial lung cryobiopsy (TBLC) succeeded in detecting metastatic adenocarcinoma, and T790M and L858R gene mutations. Pathological examination revealed a cluster of tumor cells in the intralobular interstitial areas, which was consistent with the CT findings. This report provides important information regarding the role of TBLC in diagnosing metastatic cancer, such as diffuse small miliary nodules, and its genetic mutations.

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