Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report

A 62‐year‐old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bron...

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Autores principales: Morishita, Momoko, Suzuki, Manabu, Watanabe, Hiromu, Morita, Chie, Ishida, Akane, Hashimoto, Masao, Naka, Go, Takeda, Yuichiro, Hojo, Masayuki, Sugiyama, Haruhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107029/
https://www.ncbi.nlm.nih.gov/pubmed/33755322
http://dx.doi.org/10.1111/1759-7714.13946
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author Morishita, Momoko
Suzuki, Manabu
Watanabe, Hiromu
Morita, Chie
Ishida, Akane
Hashimoto, Masao
Naka, Go
Takeda, Yuichiro
Hojo, Masayuki
Sugiyama, Haruhito
author_facet Morishita, Momoko
Suzuki, Manabu
Watanabe, Hiromu
Morita, Chie
Ishida, Akane
Hashimoto, Masao
Naka, Go
Takeda, Yuichiro
Hojo, Masayuki
Sugiyama, Haruhito
author_sort Morishita, Momoko
collection PubMed
description A 62‐year‐old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bronchoscopy was performed as metastasis was suspected; however, this was not detected on lung biopsy with forceps. Transbronchial lung cryobiopsy (TBLC) succeeded in detecting metastatic adenocarcinoma, and T790M and L858R gene mutations. Pathological examination revealed a cluster of tumor cells in the intralobular interstitial areas, which was consistent with the CT findings. This report provides important information regarding the role of TBLC in diagnosing metastatic cancer, such as diffuse small miliary nodules, and its genetic mutations.
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spelling pubmed-81070292021-05-10 Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report Morishita, Momoko Suzuki, Manabu Watanabe, Hiromu Morita, Chie Ishida, Akane Hashimoto, Masao Naka, Go Takeda, Yuichiro Hojo, Masayuki Sugiyama, Haruhito Thorac Cancer Case Reports A 62‐year‐old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bronchoscopy was performed as metastasis was suspected; however, this was not detected on lung biopsy with forceps. Transbronchial lung cryobiopsy (TBLC) succeeded in detecting metastatic adenocarcinoma, and T790M and L858R gene mutations. Pathological examination revealed a cluster of tumor cells in the intralobular interstitial areas, which was consistent with the CT findings. This report provides important information regarding the role of TBLC in diagnosing metastatic cancer, such as diffuse small miliary nodules, and its genetic mutations. John Wiley & Sons Australia, Ltd 2021-03-23 2021-05 /pmc/articles/PMC8107029/ /pubmed/33755322 http://dx.doi.org/10.1111/1759-7714.13946 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Morishita, Momoko
Suzuki, Manabu
Watanabe, Hiromu
Morita, Chie
Ishida, Akane
Hashimoto, Masao
Naka, Go
Takeda, Yuichiro
Hojo, Masayuki
Sugiyama, Haruhito
Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title_full Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title_fullStr Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title_full_unstemmed Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title_short Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
title_sort diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107029/
https://www.ncbi.nlm.nih.gov/pubmed/33755322
http://dx.doi.org/10.1111/1759-7714.13946
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