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Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI

Cerebral perforating artery flow velocity and pulsatility can be measured using 7 tesla (T) MRI. Enabling these flow metrics on more widely available 3T systems would make them more employable. It is currently unknown whether these measurements can be performed at 3T MRI due to the lower signal-to-n...

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Autores principales: Arts, Tine, Meijs, Timion A., Grotenhuis, Heynric, Voskuil, Michiel, Siero, Jeroen, Biessels, Geert Jan, Zwanenburg, Jaco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107291/
https://www.ncbi.nlm.nih.gov/pubmed/33981198
http://dx.doi.org/10.3389/fnins.2021.665480
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author Arts, Tine
Meijs, Timion A.
Grotenhuis, Heynric
Voskuil, Michiel
Siero, Jeroen
Biessels, Geert Jan
Zwanenburg, Jaco
author_facet Arts, Tine
Meijs, Timion A.
Grotenhuis, Heynric
Voskuil, Michiel
Siero, Jeroen
Biessels, Geert Jan
Zwanenburg, Jaco
author_sort Arts, Tine
collection PubMed
description Cerebral perforating artery flow velocity and pulsatility can be measured using 7 tesla (T) MRI. Enabling these flow metrics on more widely available 3T systems would make them more employable. It is currently unknown whether these measurements can be performed at 3T MRI due to the lower signal-to-noise ratio (SNR). Therefore, the aim of this study is to investigate if flow velocity and pulsatility in the perforating arteries of the basal ganglia (BG) can be measured at 3T MRI and assess the agreement with 7T MRI measurements as reference. Twenty-nine subjects were included, of which 14 patients with aortic coarctation [median age 29 years (21–72)] and 15 controls [median age 27 years (22–64)]. Using a cardiac-gated 2D phase-contrast MRI sequence BG perforating arteries were imaged at 3T and 7T MRI and perforating artery density (N(density), #/cm(2)), flow velocity (V(mean), cm/s) and pulsatility index (PI) were determined. Agreement between scanner modalities was assessed using correlation and difference plots with linear regression. A p-value ≤ 0.05 indicated statistical significance. It was shown that perforating artery flow velocity and pulsatility can be measured at 3T MRI (N(density) = 0.21 ± 0.11; V(mean) = 6.04 ± 1.27; PI = 0.49 ± 0.19), although values differed from 7T MRI measurements (N(density) = 0.95 ± 0.21; V(mean) = 3.89 ± 0.56; PI = 0.28 ± 0.08). The number of detected arteries was lower at 3T (5 ± 3) than 7T MRI (24 ± 6), indicating that 3T MRI is on average a factor 4.8 less sensitive to detect cerebral perforating arteries. Comparison with 7T MRI as reference showed some agreement in N(density), but little to no agreement for V(mean) and PI. Equalizing the modalities’ sensitivity by comparing the detected arteries on 7T MRI with the highest velocity with all vessels detected on 3T MRI, showed some improvement in agreement for PI, but not for V(mean). This study shows that it is possible to measure cerebral perforating artery flow velocity and pulsatility at 3T MRI, although an approximately fivefold sample size is needed at 3T relative to 7T MRI for a given effect size, and the measurements should be performed with equal scanner field strength and protocol.
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spelling pubmed-81072912021-05-11 Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI Arts, Tine Meijs, Timion A. Grotenhuis, Heynric Voskuil, Michiel Siero, Jeroen Biessels, Geert Jan Zwanenburg, Jaco Front Neurosci Neuroscience Cerebral perforating artery flow velocity and pulsatility can be measured using 7 tesla (T) MRI. Enabling these flow metrics on more widely available 3T systems would make them more employable. It is currently unknown whether these measurements can be performed at 3T MRI due to the lower signal-to-noise ratio (SNR). Therefore, the aim of this study is to investigate if flow velocity and pulsatility in the perforating arteries of the basal ganglia (BG) can be measured at 3T MRI and assess the agreement with 7T MRI measurements as reference. Twenty-nine subjects were included, of which 14 patients with aortic coarctation [median age 29 years (21–72)] and 15 controls [median age 27 years (22–64)]. Using a cardiac-gated 2D phase-contrast MRI sequence BG perforating arteries were imaged at 3T and 7T MRI and perforating artery density (N(density), #/cm(2)), flow velocity (V(mean), cm/s) and pulsatility index (PI) were determined. Agreement between scanner modalities was assessed using correlation and difference plots with linear regression. A p-value ≤ 0.05 indicated statistical significance. It was shown that perforating artery flow velocity and pulsatility can be measured at 3T MRI (N(density) = 0.21 ± 0.11; V(mean) = 6.04 ± 1.27; PI = 0.49 ± 0.19), although values differed from 7T MRI measurements (N(density) = 0.95 ± 0.21; V(mean) = 3.89 ± 0.56; PI = 0.28 ± 0.08). The number of detected arteries was lower at 3T (5 ± 3) than 7T MRI (24 ± 6), indicating that 3T MRI is on average a factor 4.8 less sensitive to detect cerebral perforating arteries. Comparison with 7T MRI as reference showed some agreement in N(density), but little to no agreement for V(mean) and PI. Equalizing the modalities’ sensitivity by comparing the detected arteries on 7T MRI with the highest velocity with all vessels detected on 3T MRI, showed some improvement in agreement for PI, but not for V(mean). This study shows that it is possible to measure cerebral perforating artery flow velocity and pulsatility at 3T MRI, although an approximately fivefold sample size is needed at 3T relative to 7T MRI for a given effect size, and the measurements should be performed with equal scanner field strength and protocol. Frontiers Media S.A. 2021-04-26 /pmc/articles/PMC8107291/ /pubmed/33981198 http://dx.doi.org/10.3389/fnins.2021.665480 Text en Copyright © 2021 Arts, Meijs, Grotenhuis, Voskuil, Siero, Biessels and Zwanenburg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Arts, Tine
Meijs, Timion A.
Grotenhuis, Heynric
Voskuil, Michiel
Siero, Jeroen
Biessels, Geert Jan
Zwanenburg, Jaco
Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title_full Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title_fullStr Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title_full_unstemmed Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title_short Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI
title_sort velocity and pulsatility measures in the perforating arteries of the basal ganglia at 3t mri in reference to 7t mri
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107291/
https://www.ncbi.nlm.nih.gov/pubmed/33981198
http://dx.doi.org/10.3389/fnins.2021.665480
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