Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Homozygosity for the SERPINA1 Z allele causes α(1)-antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, the effects of Z allele heterozygosity on nonrespiratory phenotypes, and on lung function in the general population, remain unclear. We conducted a large, popul...

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Detalles Bibliográficos
Autores principales: Fawcett, Katherine A., Song, Kijoung, Qian, Guoqing, Farmaki, Aliki-Eleni, Packer, Richard, John, Catherine, Shrine, Nick, Granell, Raquel, Ring, Sue, Timpson, Nicholas J., Yerges-Armstrong, Laura M., Eastell, Richard, Wain, Louise V., Scott, Robert A., Tobin, Martin D., Hall, Ian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107350/
https://www.ncbi.nlm.nih.gov/pubmed/33981765
http://dx.doi.org/10.1183/23120541.00049-2021

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