Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α

BACKGROUND: This study aimed to explore whether the mechanical stretching-induced expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in pulmonary veins occurred through the stretch-activated channel (SAC)/ mitogen-activated protein kinases (MAPKs) pathway. METHODS: Sixty male Spr...

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Detalles Bibliográficos
Autores principales: Huang, Wenhui, Liu, Hongjin, Pan, Yichao, Yang, Hongwei, Lin, Jing, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107413/
https://www.ncbi.nlm.nih.gov/pubmed/33971931
http://dx.doi.org/10.1186/s13019-021-01471-5

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