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Biological Roles and Therapeutic Applications of IDH2 Mutations in Human Cancer

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts α-KG to 2-hydroxyglutarate (2-HG), which can competit...

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Detalles Bibliográficos
Autores principales:	Guo, Jinxiu, Zhang, Ruyue, Yang, Zhe, Duan, Zhenfeng, Yin, Detao, Zhou, Yubing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107474/ https://www.ncbi.nlm.nih.gov/pubmed/33981605 http://dx.doi.org/10.3389/fonc.2021.644857

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