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Biological Roles and Therapeutic Applications of IDH2 Mutations in Human Cancer
Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts α-KG to 2-hydroxyglutarate (2-HG), which can competit...
Autores principales: | Guo, Jinxiu, Zhang, Ruyue, Yang, Zhe, Duan, Zhenfeng, Yin, Detao, Zhou, Yubing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107474/ https://www.ncbi.nlm.nih.gov/pubmed/33981605 http://dx.doi.org/10.3389/fonc.2021.644857 |
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