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Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease
BACKGROUND: Early identification of vulnerable plaques is important for patients with coronary artery disease (CAD) to reduce acute coronary events and improve their prognosis. We sought to examine the relationship between adipsin, an adipokine secreted from adipocytes, and plaque vulnerability in C...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107545/ https://www.ncbi.nlm.nih.gov/pubmed/34012589 http://dx.doi.org/10.21037/jtd-21-259 |
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author | Sun, Renhua Qiao, Yong Yan, Gaoliang Wang, Dong Zuo, Wenjie Ji, Zhenjun Zhang, Xiaoguo Yao, Yuyu Ma, Genshan Tang, Chengchun |
author_facet | Sun, Renhua Qiao, Yong Yan, Gaoliang Wang, Dong Zuo, Wenjie Ji, Zhenjun Zhang, Xiaoguo Yao, Yuyu Ma, Genshan Tang, Chengchun |
author_sort | Sun, Renhua |
collection | PubMed |
description | BACKGROUND: Early identification of vulnerable plaques is important for patients with coronary artery disease (CAD) to reduce acute coronary events and improve their prognosis. We sought to examine the relationship between adipsin, an adipokine secreted from adipocytes, and plaque vulnerability in CAD patients. METHODS: A total of 103 plaques from 99 consecutive patients who underwent coronary angiography were assessed by optical coherence tomography. The serum level of adipsin was measured using enzyme-linked immunosorbent assay (ELISA). The accuracy of adipsin for detecting thin-cap fibroatheroma (TCFA) was determined by the area under the receiver operating characteristic curve (AUC). RESULTS: Of the 99 patients, 49 were classified into the low adipsin group and 50 into the high adipsin group according to the median level of serum adipsin (2.43 µg/mL). The plaques from the high adipsin group exhibited a greater lipid index (2,700.0 vs. 1,975.9° × mm, P=0.015) and an increased proportion of TCFAs (41.2% vs. 21.2%, P=0.028) compared with the low adipsin group. Serum adipsin was found to be negatively correlated with fibrous cap thickness (ρ=−0.322, P=0.002), while it was positively correlated with average lipid arc (ρ=0.253, P=0.015), maximum lipid arc (ρ=0.211, P=0.044), lipid core length (ρ=0.241, P=0.021), lipid index (ρ=0.335, P=0.001), and vulnerability score (ρ=0.254, P=0.014). Furthermore, adipsin had a significant association with TCFAs (OR: 1.290, 95% CI: 1.048–1.589, P=0.016) in the multivariate analysis, while having a moderate diagnostic accuracy for TCFAs (AUC: 0.710, 95% CI: 0.602–0.817, P<0.001). CONCLUSIONS: Our findings suggest that serum adipsin is significantly and positively correlated with the incidence of TCFAs. The application of adipsin as a biomarker may offer improvement in the diagnosis of vulnerable plaques and clinical benefits for CAD patients. |
format | Online Article Text |
id | pubmed-8107545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-81075452021-05-18 Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease Sun, Renhua Qiao, Yong Yan, Gaoliang Wang, Dong Zuo, Wenjie Ji, Zhenjun Zhang, Xiaoguo Yao, Yuyu Ma, Genshan Tang, Chengchun J Thorac Dis Original Article BACKGROUND: Early identification of vulnerable plaques is important for patients with coronary artery disease (CAD) to reduce acute coronary events and improve their prognosis. We sought to examine the relationship between adipsin, an adipokine secreted from adipocytes, and plaque vulnerability in CAD patients. METHODS: A total of 103 plaques from 99 consecutive patients who underwent coronary angiography were assessed by optical coherence tomography. The serum level of adipsin was measured using enzyme-linked immunosorbent assay (ELISA). The accuracy of adipsin for detecting thin-cap fibroatheroma (TCFA) was determined by the area under the receiver operating characteristic curve (AUC). RESULTS: Of the 99 patients, 49 were classified into the low adipsin group and 50 into the high adipsin group according to the median level of serum adipsin (2.43 µg/mL). The plaques from the high adipsin group exhibited a greater lipid index (2,700.0 vs. 1,975.9° × mm, P=0.015) and an increased proportion of TCFAs (41.2% vs. 21.2%, P=0.028) compared with the low adipsin group. Serum adipsin was found to be negatively correlated with fibrous cap thickness (ρ=−0.322, P=0.002), while it was positively correlated with average lipid arc (ρ=0.253, P=0.015), maximum lipid arc (ρ=0.211, P=0.044), lipid core length (ρ=0.241, P=0.021), lipid index (ρ=0.335, P=0.001), and vulnerability score (ρ=0.254, P=0.014). Furthermore, adipsin had a significant association with TCFAs (OR: 1.290, 95% CI: 1.048–1.589, P=0.016) in the multivariate analysis, while having a moderate diagnostic accuracy for TCFAs (AUC: 0.710, 95% CI: 0.602–0.817, P<0.001). CONCLUSIONS: Our findings suggest that serum adipsin is significantly and positively correlated with the incidence of TCFAs. The application of adipsin as a biomarker may offer improvement in the diagnosis of vulnerable plaques and clinical benefits for CAD patients. AME Publishing Company 2021-04 /pmc/articles/PMC8107545/ /pubmed/34012589 http://dx.doi.org/10.21037/jtd-21-259 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Sun, Renhua Qiao, Yong Yan, Gaoliang Wang, Dong Zuo, Wenjie Ji, Zhenjun Zhang, Xiaoguo Yao, Yuyu Ma, Genshan Tang, Chengchun Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title | Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title_full | Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title_fullStr | Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title_full_unstemmed | Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title_short | Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
title_sort | association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107545/ https://www.ncbi.nlm.nih.gov/pubmed/34012589 http://dx.doi.org/10.21037/jtd-21-259 |
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