Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection

Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-conv...

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Detalles Bibliográficos
Autores principales: Ottaiano, Alessandro, Scala, Stefania, D’Alterio, Crescenzo, Trotta, Annamaria, Bello, Annamaria, Rea, Giuseppina, Picone, Carmine, Santorsola, Mariachiara, Petrillo, Antonella, Nasti, Guglielmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107669/
https://www.ncbi.nlm.nih.gov/pubmed/33995596
http://dx.doi.org/10.1177/17588359211011455
Descripción
Sumario:Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.

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