Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection

Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-conv...

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Autores principales: Ottaiano, Alessandro, Scala, Stefania, D’Alterio, Crescenzo, Trotta, Annamaria, Bello, Annamaria, Rea, Giuseppina, Picone, Carmine, Santorsola, Mariachiara, Petrillo, Antonella, Nasti, Guglielmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107669/
https://www.ncbi.nlm.nih.gov/pubmed/33995596
http://dx.doi.org/10.1177/17588359211011455
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author Ottaiano, Alessandro
Scala, Stefania
D’Alterio, Crescenzo
Trotta, Annamaria
Bello, Annamaria
Rea, Giuseppina
Picone, Carmine
Santorsola, Mariachiara
Petrillo, Antonella
Nasti, Guglielmo
author_facet Ottaiano, Alessandro
Scala, Stefania
D’Alterio, Crescenzo
Trotta, Annamaria
Bello, Annamaria
Rea, Giuseppina
Picone, Carmine
Santorsola, Mariachiara
Petrillo, Antonella
Nasti, Guglielmo
author_sort Ottaiano, Alessandro
collection PubMed
description Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.
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spelling pubmed-81076692021-05-14 Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection Ottaiano, Alessandro Scala, Stefania D’Alterio, Crescenzo Trotta, Annamaria Bello, Annamaria Rea, Giuseppina Picone, Carmine Santorsola, Mariachiara Petrillo, Antonella Nasti, Guglielmo Ther Adv Med Oncol Case Report Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications. SAGE Publications 2021-04-29 /pmc/articles/PMC8107669/ /pubmed/33995596 http://dx.doi.org/10.1177/17588359211011455 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Ottaiano, Alessandro
Scala, Stefania
D’Alterio, Crescenzo
Trotta, Annamaria
Bello, Annamaria
Rea, Giuseppina
Picone, Carmine
Santorsola, Mariachiara
Petrillo, Antonella
Nasti, Guglielmo
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title_full Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title_fullStr Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title_full_unstemmed Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title_short Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection
title_sort unexpected tumor reduction in metastatic colorectal cancer patients during sars-cov-2 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107669/
https://www.ncbi.nlm.nih.gov/pubmed/33995596
http://dx.doi.org/10.1177/17588359211011455
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