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Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art

The evaluation of the degree of inflammation and fibrosis, intrinsic elements in intestinal wall damage of Crohn’s disease, is essential to individuate the extent of the lesions and the presence of strictures. This information will contribute to the choice of the appropriate therapeutic approach, th...

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Autores principales: Ferretti, Francesca, Cannatelli, Rosanna, Ardizzone, Sandro, Maier, Jeanette A., Maconi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107820/
https://www.ncbi.nlm.nih.gov/pubmed/33981246
http://dx.doi.org/10.3389/fphar.2021.679924
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author Ferretti, Francesca
Cannatelli, Rosanna
Ardizzone, Sandro
Maier, Jeanette A.
Maconi, Giovanni
author_facet Ferretti, Francesca
Cannatelli, Rosanna
Ardizzone, Sandro
Maier, Jeanette A.
Maconi, Giovanni
author_sort Ferretti, Francesca
collection PubMed
description The evaluation of the degree of inflammation and fibrosis, intrinsic elements in intestinal wall damage of Crohn’s disease, is essential to individuate the extent of the lesions and the presence of strictures. This information will contribute to the choice of the appropriate therapeutic approach, the prediction of the response to therapy and the course of the disease. The accurate evaluation of the extent and severity of inflammation and/or fibrosis in Crohn’s disease currently requires histopathological analysis of the intestinal wall. However, in clinical practice and research, transmural assessment of the intestinal wall with cross sectional imaging is increasingly used for this purpose. The B-mode ultrasonograhic characteristics of the intestinal wall, the assessment of its vascularization by color Doppler and I.V. contrast agents, and the evaluation of the mechanical and elastic properties by sonoelastography, may provide useful and accurate information on the severity and extent of inflammation and intestinal fibrosis in Crohn’s disease. The purpose of this review is to provide an update on current sonographic methods to discriminate inflammation and fibrosis in Crohn’s disease.
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spelling pubmed-81078202021-05-11 Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art Ferretti, Francesca Cannatelli, Rosanna Ardizzone, Sandro Maier, Jeanette A. Maconi, Giovanni Front Pharmacol Pharmacology The evaluation of the degree of inflammation and fibrosis, intrinsic elements in intestinal wall damage of Crohn’s disease, is essential to individuate the extent of the lesions and the presence of strictures. This information will contribute to the choice of the appropriate therapeutic approach, the prediction of the response to therapy and the course of the disease. The accurate evaluation of the extent and severity of inflammation and/or fibrosis in Crohn’s disease currently requires histopathological analysis of the intestinal wall. However, in clinical practice and research, transmural assessment of the intestinal wall with cross sectional imaging is increasingly used for this purpose. The B-mode ultrasonograhic characteristics of the intestinal wall, the assessment of its vascularization by color Doppler and I.V. contrast agents, and the evaluation of the mechanical and elastic properties by sonoelastography, may provide useful and accurate information on the severity and extent of inflammation and intestinal fibrosis in Crohn’s disease. The purpose of this review is to provide an update on current sonographic methods to discriminate inflammation and fibrosis in Crohn’s disease. Frontiers Media S.A. 2021-04-26 /pmc/articles/PMC8107820/ /pubmed/33981246 http://dx.doi.org/10.3389/fphar.2021.679924 Text en Copyright © 2021 Ferretti, Cannatelli, Ardizzone, Maier and Maconi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ferretti, Francesca
Cannatelli, Rosanna
Ardizzone, Sandro
Maier, Jeanette A.
Maconi, Giovanni
Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title_full Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title_fullStr Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title_full_unstemmed Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title_short Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
title_sort ultrasonographic evaluation of intestinal fibrosis and inflammation in crohn’s disease. the state of the art
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107820/
https://www.ncbi.nlm.nih.gov/pubmed/33981246
http://dx.doi.org/10.3389/fphar.2021.679924
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