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Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma

BACKGROUND: Thyroid carcinoma is a common pediatric head and neck cancer, of which papillary thyroid cancer (PTC) is the most common type. Previously, we found that thyroid peroxidase (TPO) and aldehyde oxidase 1 (AOX1) were differentially expressed in PTC. This study explored the clinical importanc...

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Autores principales: Yu, Yongbo, Wang, Shengcai, Zhang, Xuexi, Xu, Shuai, Li, Yanzhen, Liu, Qiaoyin, Yang, Yeran, Sun, Nian, Liu, Yuanhu, Zhang, Jie, Guo, Yongli, Ni, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107839/
https://www.ncbi.nlm.nih.gov/pubmed/34012822
http://dx.doi.org/10.21037/tp-20-301
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author Yu, Yongbo
Wang, Shengcai
Zhang, Xuexi
Xu, Shuai
Li, Yanzhen
Liu, Qiaoyin
Yang, Yeran
Sun, Nian
Liu, Yuanhu
Zhang, Jie
Guo, Yongli
Ni, Xin
author_facet Yu, Yongbo
Wang, Shengcai
Zhang, Xuexi
Xu, Shuai
Li, Yanzhen
Liu, Qiaoyin
Yang, Yeran
Sun, Nian
Liu, Yuanhu
Zhang, Jie
Guo, Yongli
Ni, Xin
author_sort Yu, Yongbo
collection PubMed
description BACKGROUND: Thyroid carcinoma is a common pediatric head and neck cancer, of which papillary thyroid cancer (PTC) is the most common type. Previously, we found that thyroid peroxidase (TPO) and aldehyde oxidase 1 (AOX1) were differentially expressed in PTC. This study explored the clinical importance of TPO and AOX1 in the diagnosis and prognosis of PTC in children. METHODS: Both TPO and AOX1 expression in PTC were analyzed using datasets from Gene Expression Omnibus (GEO). TPO and AOX1 protein levels in plasma from patients with PTC and non-tumor controls were detected via enzyme-linked immunosorbent assay (ELISA). The diagnostic accuracy of TPO and AOX1 was assessed using receiver operating characteristic (ROC) curve analysis. The association between gene expression levels and patient survival was explored using the Kaplan-Meier plotter online database. RESULTS: The results revealed that TPO and AOX1 expression was significantly downregulated in four independent datasets (GSE33630, GSE27155, GSE3678, and GSE3467). TPO and AOX1 protein levels in blood plasma were significantly decreased in patients with PTC. Quantitative analysis demonstrated that TPO and AOX1 levels in plasma had satisfactory predictive performance and the ability to discriminate PTC from healthy samples. Prognostic analysis demonstrated that low levels of TPO and AOX1 were markedly associated with poor survival in patients with PTC. CONCLUSIONS: In summary, these results implied that TPO and AOX1 could serve as novel biomarkers for the diagnosis and prognosis of pediatric PTC.
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spelling pubmed-81078392021-05-18 Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma Yu, Yongbo Wang, Shengcai Zhang, Xuexi Xu, Shuai Li, Yanzhen Liu, Qiaoyin Yang, Yeran Sun, Nian Liu, Yuanhu Zhang, Jie Guo, Yongli Ni, Xin Transl Pediatr Original Article BACKGROUND: Thyroid carcinoma is a common pediatric head and neck cancer, of which papillary thyroid cancer (PTC) is the most common type. Previously, we found that thyroid peroxidase (TPO) and aldehyde oxidase 1 (AOX1) were differentially expressed in PTC. This study explored the clinical importance of TPO and AOX1 in the diagnosis and prognosis of PTC in children. METHODS: Both TPO and AOX1 expression in PTC were analyzed using datasets from Gene Expression Omnibus (GEO). TPO and AOX1 protein levels in plasma from patients with PTC and non-tumor controls were detected via enzyme-linked immunosorbent assay (ELISA). The diagnostic accuracy of TPO and AOX1 was assessed using receiver operating characteristic (ROC) curve analysis. The association between gene expression levels and patient survival was explored using the Kaplan-Meier plotter online database. RESULTS: The results revealed that TPO and AOX1 expression was significantly downregulated in four independent datasets (GSE33630, GSE27155, GSE3678, and GSE3467). TPO and AOX1 protein levels in blood plasma were significantly decreased in patients with PTC. Quantitative analysis demonstrated that TPO and AOX1 levels in plasma had satisfactory predictive performance and the ability to discriminate PTC from healthy samples. Prognostic analysis demonstrated that low levels of TPO and AOX1 were markedly associated with poor survival in patients with PTC. CONCLUSIONS: In summary, these results implied that TPO and AOX1 could serve as novel biomarkers for the diagnosis and prognosis of pediatric PTC. AME Publishing Company 2021-04 /pmc/articles/PMC8107839/ /pubmed/34012822 http://dx.doi.org/10.21037/tp-20-301 Text en 2021 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Yu, Yongbo
Wang, Shengcai
Zhang, Xuexi
Xu, Shuai
Li, Yanzhen
Liu, Qiaoyin
Yang, Yeran
Sun, Nian
Liu, Yuanhu
Zhang, Jie
Guo, Yongli
Ni, Xin
Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title_full Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title_fullStr Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title_full_unstemmed Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title_short Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma
title_sort clinical implications of tpo and aox1 in pediatric papillary thyroid carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107839/
https://www.ncbi.nlm.nih.gov/pubmed/34012822
http://dx.doi.org/10.21037/tp-20-301
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