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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1-BARD1 heterodimerization is required f...

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Detalles Bibliográficos
Autores principales:	Minten, Elizabeth V., Kapoor-Vazirani, Priya, Li, Chunyang, Zhang, Hui, Balakrishnan, Kamakshi, Yu, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108010/ https://www.ncbi.nlm.nih.gov/pubmed/33789098 http://dx.doi.org/10.1016/j.celrep.2021.108921

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