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New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation

OBJECTIVE: To evaluate the size and depth of linear lesions by in vitro testing with a custom-made radio frequency biparietal bipolar ablation catheter in a single-stage setting. METHODS: A custom-made catheter was created to generate linear lesions around the left atrium and pulmonary veins of an e...

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Autores principales: Matteucci, Francesco, Maesen, Bart, De Asmundis, Carlo, Parise, Gianmarco, Micali, Linda Renata, Tuijthof, Gabrielle, Gerits, Peter, Vernooy, Kevin, Maessen, Jos G., La Meir, Mark, Gelsomino, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108111/
https://www.ncbi.nlm.nih.gov/pubmed/33410714
http://dx.doi.org/10.1177/1556984520981025
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author Matteucci, Francesco
Maesen, Bart
De Asmundis, Carlo
Parise, Gianmarco
Micali, Linda Renata
Tuijthof, Gabrielle
Gerits, Peter
Vernooy, Kevin
Maessen, Jos G.
La Meir, Mark
Gelsomino, Sandro
author_facet Matteucci, Francesco
Maesen, Bart
De Asmundis, Carlo
Parise, Gianmarco
Micali, Linda Renata
Tuijthof, Gabrielle
Gerits, Peter
Vernooy, Kevin
Maessen, Jos G.
La Meir, Mark
Gelsomino, Sandro
author_sort Matteucci, Francesco
collection PubMed
description OBJECTIVE: To evaluate the size and depth of linear lesions by in vitro testing with a custom-made radio frequency biparietal bipolar ablation catheter in a single-stage setting. METHODS: A custom-made catheter was created to generate linear lesions around the left atrium and pulmonary veins of an ex vivo pig. Two frames were made, 1 epicardial and 1 endocardial. A continuous copper braid electrode and an alignment system consisting of 2 parallel rows of neodymium magnets were embedded in a flexible plastic support. After 24 hours of formalin conservation, samples of the left atrium of a freshly slaughtered pig were sliced in a cryotome, thus obtaining a sequence of 100-µm thick layers extending from the endocardial to the epicardial side. After being digitized through a scanner, these layers were evaluated using morphometric computer software. For each slice, we evaluated the maximum length of the lesions, the maximum epicardial length, the maximum endocardial length, the total area of the lesion, and the total volume. RESULTS: Forty transmural lesions from 40 specimens were obtained. The results were the following (the number in parenthesis is the interquartile range in mm): lesion maximum length (L (MAX)) was 7.297 mm (0.006), epicardial maximum length (L (EPI)) was 7.291 mm (0.014), and endocardial maximum length was 7.291 mm (0.018). The total area and total volume were 1018.50 ± 36.51 mm(2) and 101.85 ± 3.65 mm(3), respectively. CONCLUSIONS: Our prototype showed very promising results. The next step will be to enhance the design for clinical application.
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spelling pubmed-81081112021-05-17 New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation Matteucci, Francesco Maesen, Bart De Asmundis, Carlo Parise, Gianmarco Micali, Linda Renata Tuijthof, Gabrielle Gerits, Peter Vernooy, Kevin Maessen, Jos G. La Meir, Mark Gelsomino, Sandro Innovations (Phila) Original Articles OBJECTIVE: To evaluate the size and depth of linear lesions by in vitro testing with a custom-made radio frequency biparietal bipolar ablation catheter in a single-stage setting. METHODS: A custom-made catheter was created to generate linear lesions around the left atrium and pulmonary veins of an ex vivo pig. Two frames were made, 1 epicardial and 1 endocardial. A continuous copper braid electrode and an alignment system consisting of 2 parallel rows of neodymium magnets were embedded in a flexible plastic support. After 24 hours of formalin conservation, samples of the left atrium of a freshly slaughtered pig were sliced in a cryotome, thus obtaining a sequence of 100-µm thick layers extending from the endocardial to the epicardial side. After being digitized through a scanner, these layers were evaluated using morphometric computer software. For each slice, we evaluated the maximum length of the lesions, the maximum epicardial length, the maximum endocardial length, the total area of the lesion, and the total volume. RESULTS: Forty transmural lesions from 40 specimens were obtained. The results were the following (the number in parenthesis is the interquartile range in mm): lesion maximum length (L (MAX)) was 7.297 mm (0.006), epicardial maximum length (L (EPI)) was 7.291 mm (0.014), and endocardial maximum length was 7.291 mm (0.018). The total area and total volume were 1018.50 ± 36.51 mm(2) and 101.85 ± 3.65 mm(3), respectively. CONCLUSIONS: Our prototype showed very promising results. The next step will be to enhance the design for clinical application. SAGE Publications 2021-01-07 2021-03 /pmc/articles/PMC8108111/ /pubmed/33410714 http://dx.doi.org/10.1177/1556984520981025 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Matteucci, Francesco
Maesen, Bart
De Asmundis, Carlo
Parise, Gianmarco
Micali, Linda Renata
Tuijthof, Gabrielle
Gerits, Peter
Vernooy, Kevin
Maessen, Jos G.
La Meir, Mark
Gelsomino, Sandro
New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title_full New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title_fullStr New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title_full_unstemmed New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title_short New Biparietal Bipolar Catheter Prototype for Hybrid Atrial Fibrillation Ablation
title_sort new biparietal bipolar catheter prototype for hybrid atrial fibrillation ablation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108111/
https://www.ncbi.nlm.nih.gov/pubmed/33410714
http://dx.doi.org/10.1177/1556984520981025
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