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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance

OBJECTIVE: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the regulation of IL-23 are prerequisite for selective IL-23 targeting therapie...

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Detalles Bibliográficos
Autores principales:	Aschenbrenner, Dominik, Quaranta, Maria, Banerjee, Soumya, Ilott, Nicholas, Jansen, Joanneke, Steere, Boyd, Chen, Yin-Huai, Ho, Stephen, Cox, Karen, Arancibia-Cárcamo, Carolina V, Coles, Mark, Gaffney, Eamonn, Travis, Simon PL, Denson, Lee, Kugathasan, Subra, Schmitz, Jochen, Powrie, Fiona, Sansom, Stephen N, Uhlig, Holm H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Inflammatory Bowel Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108288/ https://www.ncbi.nlm.nih.gov/pubmed/33037057 http://dx.doi.org/10.1136/gutjnl-2020-321731

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