The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients

The extent to which tumors acquire nutrients from dietary sources as opposed to from the breakdown of host tissues is not known. In this issue of BMC Biology, Holland et al. report an approach where food sources with different isotope labeled carbon ratios can be used to answer this question, and fi...

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Detalles Bibliográficos
Autores principales: Abbott, Keene L., Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108345/
https://www.ncbi.nlm.nih.gov/pubmed/33966629
http://dx.doi.org/10.1186/s12915-021-01027-y
Descripción
Sumario:The extent to which tumors acquire nutrients from dietary sources as opposed to from the breakdown of host tissues is not known. In this issue of BMC Biology, Holland et al. report an approach where food sources with different isotope labeled carbon ratios can be used to answer this question, and find that tumors arising in Drosophila melanogaster procure most of their nutrients from the host.

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