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Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis
We compared Simoa(TM) and Ella(TM) immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella(TM) instrument overestimated values by 17%, but as th...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108418/ https://www.ncbi.nlm.nih.gov/pubmed/33830650 http://dx.doi.org/10.1002/acn3.51355 |
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| author | Gauthier, Audrey Viel, Sébastien Perret, Magali Brocard, Guillaume Casey, Romain Lombard, Christine Laurent‐Chabalier, Sabine Debouverie, Marc Edan, Gilles Vukusic, Sandra Lebrun‐Frénay, Christine De Sèze, Jérôme Laplaud, David Axel Castelnovo, Giovanni Gout, Olivier Ruet, Aurélie Moreau, Thibault Casez, Olivier Clavelou, Pierre Berger, Eric Zephir, Hélène Trouillet‐Assant, Sophie Thouvenot, Eric |
| author_facet | Gauthier, Audrey Viel, Sébastien Perret, Magali Brocard, Guillaume Casey, Romain Lombard, Christine Laurent‐Chabalier, Sabine Debouverie, Marc Edan, Gilles Vukusic, Sandra Lebrun‐Frénay, Christine De Sèze, Jérôme Laplaud, David Axel Castelnovo, Giovanni Gout, Olivier Ruet, Aurélie Moreau, Thibault Casez, Olivier Clavelou, Pierre Berger, Eric Zephir, Hélène Trouillet‐Assant, Sophie Thouvenot, Eric |
| author_sort | Gauthier, Audrey |
| collection | PubMed |
| description | We compared Simoa(TM) and Ella(TM) immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella(TM) instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella(TM) results. As for Simoa(TM), serum neurofilament‐light chain levels measured by Ella(TM) were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice. |
| format | Online Article Text |
| id | pubmed-8108418 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81084182021-05-10 Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis Gauthier, Audrey Viel, Sébastien Perret, Magali Brocard, Guillaume Casey, Romain Lombard, Christine Laurent‐Chabalier, Sabine Debouverie, Marc Edan, Gilles Vukusic, Sandra Lebrun‐Frénay, Christine De Sèze, Jérôme Laplaud, David Axel Castelnovo, Giovanni Gout, Olivier Ruet, Aurélie Moreau, Thibault Casez, Olivier Clavelou, Pierre Berger, Eric Zephir, Hélène Trouillet‐Assant, Sophie Thouvenot, Eric Ann Clin Transl Neurol Brief Communications We compared Simoa(TM) and Ella(TM) immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella(TM) instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella(TM) results. As for Simoa(TM), serum neurofilament‐light chain levels measured by Ella(TM) were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice. John Wiley and Sons Inc. 2021-04-08 /pmc/articles/PMC8108418/ /pubmed/33830650 http://dx.doi.org/10.1002/acn3.51355 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Communications Gauthier, Audrey Viel, Sébastien Perret, Magali Brocard, Guillaume Casey, Romain Lombard, Christine Laurent‐Chabalier, Sabine Debouverie, Marc Edan, Gilles Vukusic, Sandra Lebrun‐Frénay, Christine De Sèze, Jérôme Laplaud, David Axel Castelnovo, Giovanni Gout, Olivier Ruet, Aurélie Moreau, Thibault Casez, Olivier Clavelou, Pierre Berger, Eric Zephir, Hélène Trouillet‐Assant, Sophie Thouvenot, Eric Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title | Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title_full | Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title_fullStr | Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title_full_unstemmed | Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title_short | Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament‐light chain in multiple sclerosis |
| title_sort | comparison of simoa(tm) and ella(tm) to assess serum neurofilament‐light chain in multiple sclerosis |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108418/ https://www.ncbi.nlm.nih.gov/pubmed/33830650 http://dx.doi.org/10.1002/acn3.51355 |
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