CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is defined by an accumulation of immature myeloid blasts in the bone marrow. To identify key dependencies of AML stem cells in vivo, here we use a CRISPR-Cas9 screen targeting cell surface genes in a syngeneic MLL-AF9 AML mouse model and show that CXCR4 is a top cell sur...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Ramprasad, Peña-Martínez, Pablo, Agarwal, Puneet, Rodriguez-Zabala, Maria, Chapellier, Marion, Högberg, Carl, Eriksson, Mia, Yudovich, David, Shah, Mansi, Ehinger, Mats, Nilsson, Björn, Larsson, Jonas, Hagström-Andersson, Anna, Ebert, Benjamin L., Bhatia, Ravi, Järås, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109054/
https://www.ncbi.nlm.nih.gov/pubmed/32460032
http://dx.doi.org/10.1016/j.celrep.2020.107684

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