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Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model
Aging plays an important role in many diseases, including breast cancer. Aged mammary stem/progenitor cells are perceived to be the cells of origin in breast tumorigenesis; however, the extensive use of mice who have aged naturally for research is hampered by cost, time, disease complications, and h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109064/ https://www.ncbi.nlm.nih.gov/pubmed/33878032 http://dx.doi.org/10.18632/aging.202870 |
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author | Gao, Hui Liu, Yahui Zheng, Min Zhao, Fan Wang, Hongzhu Yu, Jiajian Jiang, Hao Wang, Danhan Dong, Qiaoxiang |
author_facet | Gao, Hui Liu, Yahui Zheng, Min Zhao, Fan Wang, Hongzhu Yu, Jiajian Jiang, Hao Wang, Danhan Dong, Qiaoxiang |
author_sort | Gao, Hui |
collection | PubMed |
description | Aging plays an important role in many diseases, including breast cancer. Aged mammary stem/progenitor cells are perceived to be the cells of origin in breast tumorigenesis; however, the extensive use of mice who have aged naturally for research is hampered by cost, time, disease complications, and high mortality. In this study, we characterized murine mammary stem/progenitor cells in a D-galactose-induced accelerated aging model and compared them with findings from our earlier study on mice from natural aging. Our results showed that mammary glands in the D-galactose-induced aging model mimic natural aging in terms of pathological changes, epithelial cell composition, and mammary stem/progenitor cell function. These changes are accompanied by elevated inflammatory responses both systemically in the blood and locally in the mammary glands, which is similar in mice who age naturally. Our study for the first time evaluated the mammary glands and mammary stem/progenitor function in a D-galactose-induced aging model in rodents, and our findings suggest that D-galactose treatment can be used as a surrogate to study the role aged stem/progenitor cells play in breast tumorigenesis. |
format | Online Article Text |
id | pubmed-8109064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-81090642021-05-12 Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model Gao, Hui Liu, Yahui Zheng, Min Zhao, Fan Wang, Hongzhu Yu, Jiajian Jiang, Hao Wang, Danhan Dong, Qiaoxiang Aging (Albany NY) Research Paper Aging plays an important role in many diseases, including breast cancer. Aged mammary stem/progenitor cells are perceived to be the cells of origin in breast tumorigenesis; however, the extensive use of mice who have aged naturally for research is hampered by cost, time, disease complications, and high mortality. In this study, we characterized murine mammary stem/progenitor cells in a D-galactose-induced accelerated aging model and compared them with findings from our earlier study on mice from natural aging. Our results showed that mammary glands in the D-galactose-induced aging model mimic natural aging in terms of pathological changes, epithelial cell composition, and mammary stem/progenitor cell function. These changes are accompanied by elevated inflammatory responses both systemically in the blood and locally in the mammary glands, which is similar in mice who age naturally. Our study for the first time evaluated the mammary glands and mammary stem/progenitor function in a D-galactose-induced aging model in rodents, and our findings suggest that D-galactose treatment can be used as a surrogate to study the role aged stem/progenitor cells play in breast tumorigenesis. Impact Journals 2021-04-20 /pmc/articles/PMC8109064/ /pubmed/33878032 http://dx.doi.org/10.18632/aging.202870 Text en Copyright: © 2021 Gao et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Gao, Hui Liu, Yahui Zheng, Min Zhao, Fan Wang, Hongzhu Yu, Jiajian Jiang, Hao Wang, Danhan Dong, Qiaoxiang Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title | Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title_full | Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title_fullStr | Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title_full_unstemmed | Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title_short | Characterization of murine mammary stem/progenitor cells in a D-galactose-induced aging model |
title_sort | characterization of murine mammary stem/progenitor cells in a d-galactose-induced aging model |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109064/ https://www.ncbi.nlm.nih.gov/pubmed/33878032 http://dx.doi.org/10.18632/aging.202870 |
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