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Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis
As a necessary trace element, iron is involved in many physiological processes. Clinical and basic studies have found that disturbances in iron metabolism, especially iron overload, might lead to bone loss and even be involved in postmenopausal osteoporosis. Hepcidin is a key regulator of iron homeo...
Autores principales: | Zhang, Hui, Wang, Aifei, Shen, Guangsi, Wang, Xiao, Liu, Gongwen, Yang, Fan, Chen, Bin, Wang, Mingyong, Xu, Youjia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109081/ https://www.ncbi.nlm.nih.gov/pubmed/33820875 http://dx.doi.org/10.18632/aging.202817 |
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