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High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia
Acute myeloid leukemia (AML) is a frequent malignancy in adults worldwide; identifying preferable biomarkers has become one of the current challenges. Given that COMMD7 has been reported associated with tumor progression in various human solid cancers but rarely reported in AML, herein, RNA sequenci...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109082/ https://www.ncbi.nlm.nih.gov/pubmed/33891561 http://dx.doi.org/10.18632/aging.202901 |
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author | Li, Kongfei Chen, Lieguang Zhang, Hua Wang, Lu Sha, Keya Du, Xiaohong Li, Daiyang Zheng, Zhongzheng Pei, Renzhi Lu, Ying Tong, Hongyan |
author_facet | Li, Kongfei Chen, Lieguang Zhang, Hua Wang, Lu Sha, Keya Du, Xiaohong Li, Daiyang Zheng, Zhongzheng Pei, Renzhi Lu, Ying Tong, Hongyan |
author_sort | Li, Kongfei |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a frequent malignancy in adults worldwide; identifying preferable biomarkers has become one of the current challenges. Given that COMMD7 has been reported associated with tumor progression in various human solid cancers but rarely reported in AML, herein, RNA sequencing data from TCGA and GTEx were obtained for analysis of COMMD7 expression and differentially expressed gene (DEG). Furthermore, functional enrichment analysis of COMMD7-related DEGs was performed by GO/KEGG, GSEA, immune cell infiltration analysis, and protein-protein interaction (PPI) network. In addition, the clinical significance of COMMD7 in AML was figured out by Kaplan-Meier Cox regression and prognostic nomogram model. R package was used to analyze incorporated studies. As a result, COMMD7 was highly expressed in various malignancies, including AML, compared with normal samples. Moreover, high expression of COMMD7 was associated with poor prognosis in 151 AML samples, as well as subgroups with age >60, NPM1 mutation-positive, FLT3 mutation-negative, and DNMT3A mutation-negative, et al. (P < 0.05). High COMMD7 was an independent prognostic factor in Cox regression analysis; Age and cytogenetics risk were included in the nomogram prognostic model. Furthermore, a total of 529 DEGs were identified between the high- and the low- expression group, of which 92 genes were up-regulated and 437 genes were down-regulated. Collectively, high expression of COMMD7 is a potential biomarker for adverse outcomes in AML. The DEGs and pathways recognized in the study provide a preliminary grasp of the underlying molecular mechanisms of AML carcinogenesis and progression. |
format | Online Article Text |
id | pubmed-8109082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-81090822021-05-12 High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia Li, Kongfei Chen, Lieguang Zhang, Hua Wang, Lu Sha, Keya Du, Xiaohong Li, Daiyang Zheng, Zhongzheng Pei, Renzhi Lu, Ying Tong, Hongyan Aging (Albany NY) Research Paper Acute myeloid leukemia (AML) is a frequent malignancy in adults worldwide; identifying preferable biomarkers has become one of the current challenges. Given that COMMD7 has been reported associated with tumor progression in various human solid cancers but rarely reported in AML, herein, RNA sequencing data from TCGA and GTEx were obtained for analysis of COMMD7 expression and differentially expressed gene (DEG). Furthermore, functional enrichment analysis of COMMD7-related DEGs was performed by GO/KEGG, GSEA, immune cell infiltration analysis, and protein-protein interaction (PPI) network. In addition, the clinical significance of COMMD7 in AML was figured out by Kaplan-Meier Cox regression and prognostic nomogram model. R package was used to analyze incorporated studies. As a result, COMMD7 was highly expressed in various malignancies, including AML, compared with normal samples. Moreover, high expression of COMMD7 was associated with poor prognosis in 151 AML samples, as well as subgroups with age >60, NPM1 mutation-positive, FLT3 mutation-negative, and DNMT3A mutation-negative, et al. (P < 0.05). High COMMD7 was an independent prognostic factor in Cox regression analysis; Age and cytogenetics risk were included in the nomogram prognostic model. Furthermore, a total of 529 DEGs were identified between the high- and the low- expression group, of which 92 genes were up-regulated and 437 genes were down-regulated. Collectively, high expression of COMMD7 is a potential biomarker for adverse outcomes in AML. The DEGs and pathways recognized in the study provide a preliminary grasp of the underlying molecular mechanisms of AML carcinogenesis and progression. Impact Journals 2021-04-23 /pmc/articles/PMC8109082/ /pubmed/33891561 http://dx.doi.org/10.18632/aging.202901 Text en Copyright: © 2021 Li et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Li, Kongfei Chen, Lieguang Zhang, Hua Wang, Lu Sha, Keya Du, Xiaohong Li, Daiyang Zheng, Zhongzheng Pei, Renzhi Lu, Ying Tong, Hongyan High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title | High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title_full | High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title_fullStr | High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title_full_unstemmed | High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title_short | High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia |
title_sort | high expression of commd7 is an adverse prognostic factor in acute myeloid leukemia |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109082/ https://www.ncbi.nlm.nih.gov/pubmed/33891561 http://dx.doi.org/10.18632/aging.202901 |
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