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Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma

Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific diagnostic models by screening lymphoma marker genes. Transcript...

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Autores principales: Li, Wen-Xing, Dai, Shao-Xing, An, San-Qi, Sun, Tingting, Liu, Justin, Wang, Jun, Liu, Leyna G., Xun, Yang, Yang, Hua, Fan, Li-Xia, Zhang, Xiao-Li, Liao, Wan-Qin, You, Hua, Tamagnone, Luca, Liu, Fang, Huang, Jing-Fei, Liu, Dahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109084/
https://www.ncbi.nlm.nih.gov/pubmed/33885377
http://dx.doi.org/10.18632/aging.202882
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author Li, Wen-Xing
Dai, Shao-Xing
An, San-Qi
Sun, Tingting
Liu, Justin
Wang, Jun
Liu, Leyna G.
Xun, Yang
Yang, Hua
Fan, Li-Xia
Zhang, Xiao-Li
Liao, Wan-Qin
You, Hua
Tamagnone, Luca
Liu, Fang
Huang, Jing-Fei
Liu, Dahai
author_facet Li, Wen-Xing
Dai, Shao-Xing
An, San-Qi
Sun, Tingting
Liu, Justin
Wang, Jun
Liu, Leyna G.
Xun, Yang
Yang, Hua
Fan, Li-Xia
Zhang, Xiao-Li
Liao, Wan-Qin
You, Hua
Tamagnone, Luca
Liu, Fang
Huang, Jing-Fei
Liu, Dahai
author_sort Li, Wen-Xing
collection PubMed
description Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific diagnostic models by screening lymphoma marker genes. Transcriptome data of HL, DLBCL, and MCL were obtained from public databases. Lymphoma marker genes were screened by comparing cases and controls as well as the intergroup differences among lymphomas. A total of 9 HL marker genes, 7 DLBCL marker genes, and 4 MCL marker genes were screened in this study. Most HL marker genes were upregulated, whereas DLBCL and MCL marker genes were downregulated compared to controls. The optimal HL-specific diagnostic model contains one marker gene (MYH2) with an AUC of 0.901. The optimal DLBCL-specific diagnostic model contains 7 marker genes (LIPF, CCDC144B, PRO2964, PHF1, SFTPA2, NTS, and HP) with an AUC of 0.951. The optimal MCL-specific diagnostic model contains 3 marker genes (IGLV3-19, IGKV4-1, and PRB3) with an AUC of 0.843. The present study reveals the transcriptome data-based differences between HL, DLBCL, and MCL, when combined with other clinical markers, may help the clinical diagnosis and prognosis.
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spelling pubmed-81090842021-05-12 Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma Li, Wen-Xing Dai, Shao-Xing An, San-Qi Sun, Tingting Liu, Justin Wang, Jun Liu, Leyna G. Xun, Yang Yang, Hua Fan, Li-Xia Zhang, Xiao-Li Liao, Wan-Qin You, Hua Tamagnone, Luca Liu, Fang Huang, Jing-Fei Liu, Dahai Aging (Albany NY) Research Paper Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific diagnostic models by screening lymphoma marker genes. Transcriptome data of HL, DLBCL, and MCL were obtained from public databases. Lymphoma marker genes were screened by comparing cases and controls as well as the intergroup differences among lymphomas. A total of 9 HL marker genes, 7 DLBCL marker genes, and 4 MCL marker genes were screened in this study. Most HL marker genes were upregulated, whereas DLBCL and MCL marker genes were downregulated compared to controls. The optimal HL-specific diagnostic model contains one marker gene (MYH2) with an AUC of 0.901. The optimal DLBCL-specific diagnostic model contains 7 marker genes (LIPF, CCDC144B, PRO2964, PHF1, SFTPA2, NTS, and HP) with an AUC of 0.951. The optimal MCL-specific diagnostic model contains 3 marker genes (IGLV3-19, IGKV4-1, and PRB3) with an AUC of 0.843. The present study reveals the transcriptome data-based differences between HL, DLBCL, and MCL, when combined with other clinical markers, may help the clinical diagnosis and prognosis. Impact Journals 2021-04-22 /pmc/articles/PMC8109084/ /pubmed/33885377 http://dx.doi.org/10.18632/aging.202882 Text en Copyright: © 2021 Li et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Wen-Xing
Dai, Shao-Xing
An, San-Qi
Sun, Tingting
Liu, Justin
Wang, Jun
Liu, Leyna G.
Xun, Yang
Yang, Hua
Fan, Li-Xia
Zhang, Xiao-Li
Liao, Wan-Qin
You, Hua
Tamagnone, Luca
Liu, Fang
Huang, Jing-Fei
Liu, Dahai
Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title_full Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title_fullStr Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title_full_unstemmed Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title_short Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma
title_sort transcriptome integration analysis and specific diagnosis model construction for hodgkin's lymphoma, diffuse large b-cell lymphoma, and mantle cell lymphoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109084/
https://www.ncbi.nlm.nih.gov/pubmed/33885377
http://dx.doi.org/10.18632/aging.202882
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