Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. Its...

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Detalles Bibliográficos
Autores principales: Ma, Yuting, Liu, Yongping, Han, Fang, Qiu, Hongyan, Shi, Junfeng, Huang, Na, Hou, Ningning, Sun, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109099/
https://www.ncbi.nlm.nih.gov/pubmed/33886503
http://dx.doi.org/10.18632/aging.202881
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author Ma, Yuting
Liu, Yongping
Han, Fang
Qiu, Hongyan
Shi, Junfeng
Huang, Na
Hou, Ningning
Sun, Xiaodong
author_facet Ma, Yuting
Liu, Yongping
Han, Fang
Qiu, Hongyan
Shi, Junfeng
Huang, Na
Hou, Ningning
Sun, Xiaodong
author_sort Ma, Yuting
collection PubMed
description Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. Its wide-ranging biological effects may include the reversal of senescence in clinical applications, as well as the ability to reverse age-related pathological changes and regulate organ regeneration after injury. Nevertheless, recent data have led to controversy regarding the functional roles of GDF11, because the underlying mechanisms were not clearly established in previous studies. In this review, we examine the literature regarding GDF11 in age-related diseases and discuss potential mechanisms underlying the effects of GDF11 in regulation of age-related diseases.
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spelling pubmed-81090992021-05-12 Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases? Ma, Yuting Liu, Yongping Han, Fang Qiu, Hongyan Shi, Junfeng Huang, Na Hou, Ningning Sun, Xiaodong Aging (Albany NY) Review Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. Its wide-ranging biological effects may include the reversal of senescence in clinical applications, as well as the ability to reverse age-related pathological changes and regulate organ regeneration after injury. Nevertheless, recent data have led to controversy regarding the functional roles of GDF11, because the underlying mechanisms were not clearly established in previous studies. In this review, we examine the literature regarding GDF11 in age-related diseases and discuss potential mechanisms underlying the effects of GDF11 in regulation of age-related diseases. Impact Journals 2021-04-22 /pmc/articles/PMC8109099/ /pubmed/33886503 http://dx.doi.org/10.18632/aging.202881 Text en Copyright: © 2021 Ma et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Ma, Yuting
Liu, Yongping
Han, Fang
Qiu, Hongyan
Shi, Junfeng
Huang, Na
Hou, Ningning
Sun, Xiaodong
Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title_full Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title_fullStr Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title_full_unstemmed Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title_short Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
title_sort growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109099/
https://www.ncbi.nlm.nih.gov/pubmed/33886503
http://dx.doi.org/10.18632/aging.202881
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