Cargando…

Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study

OBJECTIVE: To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterize neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively- and passively-acquired SARS-CoV-2 antibodies in...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Dongli, Prahl, Mary, Gaw, Stephanie L., Narasimhan, SudhaRani, Rai, Daljeet, Huang, Angela, Flores, Claudia, Lin, Christine Y., Jigmeddagva, Unurzul, Wu, Alan H.B., Warrier, Lakshmi, Levan, Justine, Nguyen, Catherine B.T., Callaway, Perri, Farrington, Lila, Acevedo, Gonzalo R., Gonzalez, Veronica J., Vaaben, Anna, Nguyen, Phuong, Atmosfera, Elda, Marleau, Constance, Anderson, Christina, Misra, Sonya, Stemmle, Monica, Cortes, Maria, McAuley, Jennifer, Metz, Nicole, Patel, Rupalee, Nudelman, Matthew, Abraham, Susan, Byrne, James, Jegatheesan, Priya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109203/
https://www.ncbi.nlm.nih.gov/pubmed/33972953
http://dx.doi.org/10.1101/2021.05.01.21255871
_version_ 1783690209948336128
author Song, Dongli
Prahl, Mary
Gaw, Stephanie L.
Narasimhan, SudhaRani
Rai, Daljeet
Huang, Angela
Flores, Claudia
Lin, Christine Y.
Jigmeddagva, Unurzul
Wu, Alan H.B.
Warrier, Lakshmi
Levan, Justine
Nguyen, Catherine B.T.
Callaway, Perri
Farrington, Lila
Acevedo, Gonzalo R.
Gonzalez, Veronica J.
Vaaben, Anna
Nguyen, Phuong
Atmosfera, Elda
Marleau, Constance
Anderson, Christina
Misra, Sonya
Stemmle, Monica
Cortes, Maria
McAuley, Jennifer
Metz, Nicole
Patel, Rupalee
Nudelman, Matthew
Abraham, Susan
Byrne, James
Jegatheesan, Priya
author_facet Song, Dongli
Prahl, Mary
Gaw, Stephanie L.
Narasimhan, SudhaRani
Rai, Daljeet
Huang, Angela
Flores, Claudia
Lin, Christine Y.
Jigmeddagva, Unurzul
Wu, Alan H.B.
Warrier, Lakshmi
Levan, Justine
Nguyen, Catherine B.T.
Callaway, Perri
Farrington, Lila
Acevedo, Gonzalo R.
Gonzalez, Veronica J.
Vaaben, Anna
Nguyen, Phuong
Atmosfera, Elda
Marleau, Constance
Anderson, Christina
Misra, Sonya
Stemmle, Monica
Cortes, Maria
McAuley, Jennifer
Metz, Nicole
Patel, Rupalee
Nudelman, Matthew
Abraham, Susan
Byrne, James
Jegatheesan, Priya
author_sort Song, Dongli
collection PubMed
description OBJECTIVE: To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterize neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively- and passively-acquired SARS-CoV-2 antibodies in infants. DESIGN: A prospective observational study. SETTING: A public healthcare system in Santa Clara County (CA, USA). PARTICIPANTS: Women with SARS-CoV-2 infection during pregnancy and their infants were enrolled between April 15, 2020 and March 31, 2021. OUTCOMES: SARS-CoV-2 serology analyses in the cord and maternal blood at delivery and longitudinally in infant blood between birth and 28 weeks of life. RESULTS: Of 145 mothers who tested positive for SARS-CoV-2 during pregnancy, 86 had symptomatic infections: 78 with mild-moderate symptoms, and eight with severe-critical symptoms. Of the 147 newborns, two infants showed seroconversion at two weeks of age with high levels of IgM and IgG, including one premature infant with confirmed intrapartum infection. The seropositivity rates of the mothers at delivery was 65% (95% CI 0.56-0.73) and the cord blood was 58% (95% CI 0.49-0.66). IgG levels significantly correlated between the maternal and cord blood (Rs= 0.93, p< 0.0001). IgG transplacental transfer ratio was significantly higher when the first maternal positive PCR was 60-180 days before delivery compared to <60 days (1.2 vs. 0.6, p=<0.0001). Infant IgG negative conversion rate over follow-up periods of 1-4, 5-12, and 13-28 weeks were 8% (4/48), 12% (3/25), and 38% (5/13), respectively. The IgG seropositivity in the infants was positively related to IgG levels in the cord blood and persisted up to six months of age. CONCLUSIONS: Maternal SARS-CoV-2 IgG is efficiently transferred across the placenta when infections occur more than two months before delivery. Maternally-derived passive immunity may protect infants up to six months of life. Neonates mount a strong antibody response to perinatal SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-8109203
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-81092032021-05-11 Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study Song, Dongli Prahl, Mary Gaw, Stephanie L. Narasimhan, SudhaRani Rai, Daljeet Huang, Angela Flores, Claudia Lin, Christine Y. Jigmeddagva, Unurzul Wu, Alan H.B. Warrier, Lakshmi Levan, Justine Nguyen, Catherine B.T. Callaway, Perri Farrington, Lila Acevedo, Gonzalo R. Gonzalez, Veronica J. Vaaben, Anna Nguyen, Phuong Atmosfera, Elda Marleau, Constance Anderson, Christina Misra, Sonya Stemmle, Monica Cortes, Maria McAuley, Jennifer Metz, Nicole Patel, Rupalee Nudelman, Matthew Abraham, Susan Byrne, James Jegatheesan, Priya medRxiv Article OBJECTIVE: To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterize neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively- and passively-acquired SARS-CoV-2 antibodies in infants. DESIGN: A prospective observational study. SETTING: A public healthcare system in Santa Clara County (CA, USA). PARTICIPANTS: Women with SARS-CoV-2 infection during pregnancy and their infants were enrolled between April 15, 2020 and March 31, 2021. OUTCOMES: SARS-CoV-2 serology analyses in the cord and maternal blood at delivery and longitudinally in infant blood between birth and 28 weeks of life. RESULTS: Of 145 mothers who tested positive for SARS-CoV-2 during pregnancy, 86 had symptomatic infections: 78 with mild-moderate symptoms, and eight with severe-critical symptoms. Of the 147 newborns, two infants showed seroconversion at two weeks of age with high levels of IgM and IgG, including one premature infant with confirmed intrapartum infection. The seropositivity rates of the mothers at delivery was 65% (95% CI 0.56-0.73) and the cord blood was 58% (95% CI 0.49-0.66). IgG levels significantly correlated between the maternal and cord blood (Rs= 0.93, p< 0.0001). IgG transplacental transfer ratio was significantly higher when the first maternal positive PCR was 60-180 days before delivery compared to <60 days (1.2 vs. 0.6, p=<0.0001). Infant IgG negative conversion rate over follow-up periods of 1-4, 5-12, and 13-28 weeks were 8% (4/48), 12% (3/25), and 38% (5/13), respectively. The IgG seropositivity in the infants was positively related to IgG levels in the cord blood and persisted up to six months of age. CONCLUSIONS: Maternal SARS-CoV-2 IgG is efficiently transferred across the placenta when infections occur more than two months before delivery. Maternally-derived passive immunity may protect infants up to six months of life. Neonates mount a strong antibody response to perinatal SARS-CoV-2 infection. Cold Spring Harbor Laboratory 2021-05-03 /pmc/articles/PMC8109203/ /pubmed/33972953 http://dx.doi.org/10.1101/2021.05.01.21255871 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Song, Dongli
Prahl, Mary
Gaw, Stephanie L.
Narasimhan, SudhaRani
Rai, Daljeet
Huang, Angela
Flores, Claudia
Lin, Christine Y.
Jigmeddagva, Unurzul
Wu, Alan H.B.
Warrier, Lakshmi
Levan, Justine
Nguyen, Catherine B.T.
Callaway, Perri
Farrington, Lila
Acevedo, Gonzalo R.
Gonzalez, Veronica J.
Vaaben, Anna
Nguyen, Phuong
Atmosfera, Elda
Marleau, Constance
Anderson, Christina
Misra, Sonya
Stemmle, Monica
Cortes, Maria
McAuley, Jennifer
Metz, Nicole
Patel, Rupalee
Nudelman, Matthew
Abraham, Susan
Byrne, James
Jegatheesan, Priya
Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title_full Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title_fullStr Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title_full_unstemmed Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title_short Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study
title_sort passive and active immunity in infants born to mothers with sars-cov-2 infection during pregnancy: prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109203/
https://www.ncbi.nlm.nih.gov/pubmed/33972953
http://dx.doi.org/10.1101/2021.05.01.21255871
work_keys_str_mv AT songdongli passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT prahlmary passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT gawstephaniel passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT narasimhansudharani passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT raidaljeet passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT huangangela passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT floresclaudia passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT linchristiney passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT jigmeddagvaunurzul passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT wualanhb passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT warrierlakshmi passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT levanjustine passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT nguyencatherinebt passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT callawayperri passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT farringtonlila passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT acevedogonzalor passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT gonzalezveronicaj passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT vaabenanna passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT nguyenphuong passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT atmosferaelda passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT marleauconstance passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT andersonchristina passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT misrasonya passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT stemmlemonica passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT cortesmaria passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT mcauleyjennifer passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT metznicole passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT patelrupalee passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT nudelmanmatthew passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT abrahamsusan passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT byrnejames passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy
AT jegatheesanpriya passiveandactiveimmunityininfantsborntomotherswithsarscov2infectionduringpregnancyprospectivecohortstudy