Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K27M preferentially within the hindbrain. The reason...

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Detalles Bibliográficos
Autores principales: Bressan, Raul Bardini, Southgate, Benjamin, Ferguson, Kirsty M., Blin, Carla, Grant, Vivien, Alfazema, Neza, Wills, Jimi C., Marques-Torrejon, Maria Angeles, Morrison, Gillian M., Ashmore, James, Robertson, Faye, Williams, Charles A.C., Bradley, Leanne, von Kriegsheim, Alex, Anderson, Richard A., Tomlinson, Simon R., Pollard, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110245/
https://www.ncbi.nlm.nih.gov/pubmed/33631116
http://dx.doi.org/10.1016/j.stem.2021.01.016

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