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A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review
Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left b...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110257/ https://www.ncbi.nlm.nih.gov/pubmed/33986601 http://dx.doi.org/10.2147/OTT.S298379 |
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author | Tu He Ta Mi Shi, Mei Er Wang, Ning Yao, Qing Dong, Shuang-Shuang Feng, Xiao Zhao, Jin Zou, Hong Pang, Li-Juan Qi, Yan |
author_facet | Tu He Ta Mi Shi, Mei Er Wang, Ning Yao, Qing Dong, Shuang-Shuang Feng, Xiao Zhao, Jin Zou, Hong Pang, Li-Juan Qi, Yan |
author_sort | Tu He Ta Mi Shi, Mei Er |
collection | PubMed |
description | Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Twenty years later, the lump suddenly grew within 1 month. Mammography showed space-occupying lesions of the left breast. Histologically, the tumor was characterized by hypercellular stroma covering the epithelium and protrusion of the myoepithelium into the cyst to form a lobulated structure; regions of loose mucus and hypercellular structures alternated. A region of peripheral benign fibroadenoma was also observed, and many stellate and spindle cells or signet ring-like cells were identified in loose areas. Some areas showed a characteristic thin branching vascular pattern. In the cell-rich area, adipocytes and odd megakaryocytes were observed. Atypical mitotic figures were observed in the cell-rich and mucus areas (16 mitoses/10 high-power fields [HPF] and 2 mitoses/10 HPF, respectively). In the immunohistochemical analysis, a small number of tumor cells were positive for AE1/3 and vimentin, whereas all cells were negative for cytokeratin 34βE12, E-cadherin, p63, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and S-100, ruling out the possibility of metaplastic carcinoma. Interestingly, cyclin-dependent kinase 4, mouse double minute 2 (MDM2), and p16 were strongly positive in both loose mucus and cell-rich areas. However, the fluorescence in situ hybridization test results showed that MDM2 was not amplified. Combined with morphological characteristics, these findings supported that the tumor was a mixed malignant PT with MLP and PLP. Our patient did not receive radiation therapy, and after 47 months of follow-up, no recurrence or metastasis occurred. This case report serves to expand the morphologic spectrum of mixed malignant PT with liposarcoma. |
format | Online Article Text |
id | pubmed-8110257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81102572021-05-12 A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review Tu He Ta Mi Shi, Mei Er Wang, Ning Yao, Qing Dong, Shuang-Shuang Feng, Xiao Zhao, Jin Zou, Hong Pang, Li-Juan Qi, Yan Onco Targets Ther Case Report Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Twenty years later, the lump suddenly grew within 1 month. Mammography showed space-occupying lesions of the left breast. Histologically, the tumor was characterized by hypercellular stroma covering the epithelium and protrusion of the myoepithelium into the cyst to form a lobulated structure; regions of loose mucus and hypercellular structures alternated. A region of peripheral benign fibroadenoma was also observed, and many stellate and spindle cells or signet ring-like cells were identified in loose areas. Some areas showed a characteristic thin branching vascular pattern. In the cell-rich area, adipocytes and odd megakaryocytes were observed. Atypical mitotic figures were observed in the cell-rich and mucus areas (16 mitoses/10 high-power fields [HPF] and 2 mitoses/10 HPF, respectively). In the immunohistochemical analysis, a small number of tumor cells were positive for AE1/3 and vimentin, whereas all cells were negative for cytokeratin 34βE12, E-cadherin, p63, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and S-100, ruling out the possibility of metaplastic carcinoma. Interestingly, cyclin-dependent kinase 4, mouse double minute 2 (MDM2), and p16 were strongly positive in both loose mucus and cell-rich areas. However, the fluorescence in situ hybridization test results showed that MDM2 was not amplified. Combined with morphological characteristics, these findings supported that the tumor was a mixed malignant PT with MLP and PLP. Our patient did not receive radiation therapy, and after 47 months of follow-up, no recurrence or metastasis occurred. This case report serves to expand the morphologic spectrum of mixed malignant PT with liposarcoma. Dove 2021-05-06 /pmc/articles/PMC8110257/ /pubmed/33986601 http://dx.doi.org/10.2147/OTT.S298379 Text en © 2021 Tu He Ta Mi Shi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Tu He Ta Mi Shi, Mei Er Wang, Ning Yao, Qing Dong, Shuang-Shuang Feng, Xiao Zhao, Jin Zou, Hong Pang, Li-Juan Qi, Yan A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title | A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title_full | A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title_fullStr | A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title_full_unstemmed | A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title_short | A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review |
title_sort | case of phyllodes tumor of the breast with mixed liposarcoma: case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110257/ https://www.ncbi.nlm.nih.gov/pubmed/33986601 http://dx.doi.org/10.2147/OTT.S298379 |
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