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Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome

BACKGROUNDS: Adiponectin (apM1) may affect insulin sensitivity, and tumor necrosis factor (TNF-α) can inhibit the binding of insulin and insulin receptors. However, whether apM1 and TNF-α genes influence the development of metabolic syndrome (MetS) preceded by insulin resistance is unclear. The curr...

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Autores principales: Chen, Chun-Chieh, Wei, Yu-Hsiang, Huang, Chia-Chen, Hung, Shin-Hui, Wang, Zeng-Wei, Wong, Ruey-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110375/
https://www.ncbi.nlm.nih.gov/pubmed/33997011
http://dx.doi.org/10.1155/2021/5570827
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author Chen, Chun-Chieh
Wei, Yu-Hsiang
Huang, Chia-Chen
Hung, Shin-Hui
Wang, Zeng-Wei
Wong, Ruey-Hong
author_facet Chen, Chun-Chieh
Wei, Yu-Hsiang
Huang, Chia-Chen
Hung, Shin-Hui
Wang, Zeng-Wei
Wong, Ruey-Hong
author_sort Chen, Chun-Chieh
collection PubMed
description BACKGROUNDS: Adiponectin (apM1) may affect insulin sensitivity, and tumor necrosis factor (TNF-α) can inhibit the binding of insulin and insulin receptors. However, whether apM1 and TNF-α genes influence the development of metabolic syndrome (MetS) preceded by insulin resistance is unclear. The current study examines the interactions between the apM1 +45 genotypes, TNF-α -308 genotypes, and insulin resistance on the occurrence of MetS. METHODS: A total of 329 community residents were recruited, and their personal characteristics were collected. Waist circumference and biochemical markers were examined for determining MetS. Genotypes were identified by the polymerase chain reaction. RESULTS: After adjusting for the confounding effects, compared to apM1 +45 GG and GT genotypes carriers with HOMR-IR less than 2.0, those carriers with HOMA-IR greater than 2.0 had an increased MetS risk (OR = 4.35, 95% CI 2.14-8.85). Further, apM1 +45 TT carriers with HOMA-IR greater than 2.0 experienced a higher MetS risk (OR = 5.91, 95% CI 2.78-12.54). A significant interaction of the apM1 +45 genotype and insulin resistance on the MetS development was observed (P = 0.04). CONCLUSION: Our data suggested that apM1 +45 genotypes might modify the effect of insulin resistance on the development of Taiwanese MetS.
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spelling pubmed-81103752021-05-13 Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome Chen, Chun-Chieh Wei, Yu-Hsiang Huang, Chia-Chen Hung, Shin-Hui Wang, Zeng-Wei Wong, Ruey-Hong Biomed Res Int Research Article BACKGROUNDS: Adiponectin (apM1) may affect insulin sensitivity, and tumor necrosis factor (TNF-α) can inhibit the binding of insulin and insulin receptors. However, whether apM1 and TNF-α genes influence the development of metabolic syndrome (MetS) preceded by insulin resistance is unclear. The current study examines the interactions between the apM1 +45 genotypes, TNF-α -308 genotypes, and insulin resistance on the occurrence of MetS. METHODS: A total of 329 community residents were recruited, and their personal characteristics were collected. Waist circumference and biochemical markers were examined for determining MetS. Genotypes were identified by the polymerase chain reaction. RESULTS: After adjusting for the confounding effects, compared to apM1 +45 GG and GT genotypes carriers with HOMR-IR less than 2.0, those carriers with HOMA-IR greater than 2.0 had an increased MetS risk (OR = 4.35, 95% CI 2.14-8.85). Further, apM1 +45 TT carriers with HOMA-IR greater than 2.0 experienced a higher MetS risk (OR = 5.91, 95% CI 2.78-12.54). A significant interaction of the apM1 +45 genotype and insulin resistance on the MetS development was observed (P = 0.04). CONCLUSION: Our data suggested that apM1 +45 genotypes might modify the effect of insulin resistance on the development of Taiwanese MetS. Hindawi 2021-04-30 /pmc/articles/PMC8110375/ /pubmed/33997011 http://dx.doi.org/10.1155/2021/5570827 Text en Copyright © 2021 Chun-Chieh Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Chun-Chieh
Wei, Yu-Hsiang
Huang, Chia-Chen
Hung, Shin-Hui
Wang, Zeng-Wei
Wong, Ruey-Hong
Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title_full Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title_fullStr Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title_full_unstemmed Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title_short Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
title_sort interaction of adiponectin genotypes and insulin resistance on the occurrence of taiwanese metabolic syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110375/
https://www.ncbi.nlm.nih.gov/pubmed/33997011
http://dx.doi.org/10.1155/2021/5570827
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