Ethically utilising COVID-19 host-genomic data

Genetic variants that influence susceptibility to COVID-19 have recently been identified. In this manuscript, we identify and discuss some of the ethical and practical issues raised by these studies. We first outline the ethical case for providing COVID-19 susceptibility testing to healthcare worker...

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Autores principales: Gyngell, Christopher, Christodoulou, John, Savulescu, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110518/
https://www.ncbi.nlm.nih.gov/pubmed/33972547
http://dx.doi.org/10.1038/s41525-021-00194-9
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author Gyngell, Christopher
Christodoulou, John
Savulescu, Julian
author_facet Gyngell, Christopher
Christodoulou, John
Savulescu, Julian
author_sort Gyngell, Christopher
collection PubMed
description Genetic variants that influence susceptibility to COVID-19 have recently been identified. In this manuscript, we identify and discuss some of the ethical and practical issues raised by these studies. We first outline the ethical case for providing COVID-19 susceptibility testing to healthcare workers, as well as highlighting risks associated with privacy and discrimination. We then argue that the existence of genetically susceptible individuals has implications for the ethical conduct of COVID-19 human challenge trials. Finally, we discuss the ethical issues that could arise from other COVID-19 host–genome interactions, including the prospect of personalized vaccines.
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spelling pubmed-81105182021-05-11 Ethically utilising COVID-19 host-genomic data Gyngell, Christopher Christodoulou, John Savulescu, Julian NPJ Genom Med Comment Genetic variants that influence susceptibility to COVID-19 have recently been identified. In this manuscript, we identify and discuss some of the ethical and practical issues raised by these studies. We first outline the ethical case for providing COVID-19 susceptibility testing to healthcare workers, as well as highlighting risks associated with privacy and discrimination. We then argue that the existence of genetically susceptible individuals has implications for the ethical conduct of COVID-19 human challenge trials. Finally, we discuss the ethical issues that could arise from other COVID-19 host–genome interactions, including the prospect of personalized vaccines. Nature Publishing Group UK 2021-05-10 /pmc/articles/PMC8110518/ /pubmed/33972547 http://dx.doi.org/10.1038/s41525-021-00194-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Gyngell, Christopher
Christodoulou, John
Savulescu, Julian
Ethically utilising COVID-19 host-genomic data
title Ethically utilising COVID-19 host-genomic data
title_full Ethically utilising COVID-19 host-genomic data
title_fullStr Ethically utilising COVID-19 host-genomic data
title_full_unstemmed Ethically utilising COVID-19 host-genomic data
title_short Ethically utilising COVID-19 host-genomic data
title_sort ethically utilising covid-19 host-genomic data
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110518/
https://www.ncbi.nlm.nih.gov/pubmed/33972547
http://dx.doi.org/10.1038/s41525-021-00194-9
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