Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations

Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors. To investigate how the oncohistone mutation affects the function of SETD2 at the nucleosome level, we determined the cryo-EM structure o...

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Detalles Bibliográficos
Autores principales: Liu, Yingying, Zhang, Yanjun, Xue, Han, Cao, Mi, Bai, Guohui, Mu, Zongkai, Yao, Yanli, Sun, Shuyang, Fang, Dong, Huang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110526/
https://www.ncbi.nlm.nih.gov/pubmed/33972509
http://dx.doi.org/10.1038/s41421-021-00261-6

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