Cargando…

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRIG1 as an important regulator. We show that BMP-4 s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marqués-Torrejón, María Ángeles, Williams, Charles A. C., Southgate, Benjamin, Alfazema, Neza, Clements, Melanie P., Garcia-Diaz, Claudia, Blin, Carla, Arranz-Emparan, Nerea, Fraser, Jane, Gammoh, Noor, Parrinello, Simona, Pollard, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110534/ https://www.ncbi.nlm.nih.gov/pubmed/33972529 http://dx.doi.org/10.1038/s41467-021-22813-w

Ejemplares similares

Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells
por: Ferguson, Kirsty M., et al.
Publicado: (2022)

HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?
por: Herdenberg, Carl, et al.
Publicado: (2022)

LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor
por: Ji, Yibing, et al.
Publicado: (2022)

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells
por: Mohammad, Karamat, et al.
Publicado: (2019)

Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence
por: Peselj, Carlotta, et al.
Publicado: (2022)

Molecular control of cell density-mediated exit to quiescence
por: Fan, Yilin, et al.
Publicado: (2021)

Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling
por: Lawlor, Katerina, et al.
Publicado: (2020)

Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants
por: Bressan, Raul Bardini, et al.
Publicado: (2021)

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
por: Gangoso, Ester, et al.
Publicado: (2021)

Polarized Growth in the Absence of F-Actin in Saccharomyces cerevisiae Exiting Quiescence
por: Sahin, Annelise, et al.
Publicado: (2008)

Yeast quiescence exit swiftness is influenced by cell volume and chronological age
por: Laporte, Damien, et al.
Publicado: (2017)

Exit from quiescence displays a memory of cell growth and division
por: Wang, Xia, et al.
Publicado: (2017)

The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2019)

Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence
por: Chell, James M., et al.
Publicado: (2010)

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
por: Laurenti, Elisa, et al.
Publicado: (2015)

Imp is required for timely exit from quiescence in Drosophila type II neuroblasts
por: Munroe, Jordan A., et al.
Publicado: (2022)

Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest
por: Johnson, Martha Sharisha, et al.
Publicado: (2023)

LRIG and cancer prognosis
por: Lindquist, David, et al.
Publicado: (2014)

Corrigendum: The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2020)

Metabolic status rather than cell cycle signals control quiescence entry and exit
por: Laporte, Damien, et al.
Publicado: (2011)

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation
por: Yang, Hee Won, et al.
Publicado: (2020)

HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
por: Marinopoulou, Elli, et al.
Publicado: (2021)

Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
por: Lång, Emma, et al.
Publicado: (2022)

A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit
por: Laporte, Damien, et al.
Publicado: (2015)

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
por: Mohrin, Mary, et al.
Publicado: (2018)

A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells
por: Zhou, Shaopu, et al.
Publicado: (2022)

Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence Exit
por: Lyublinskaya, O. G., et al.
Publicado: (2015)

The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
por: Gonzalez, Laura, et al.
Publicado: (2023)

Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
por: Amodeo, Valeria, et al.
Publicado: (2023)

Give it a REST!
por: Pollard, Steven M, et al.
Publicado: (2016)

LRIG1 expression and colorectal cancer prognosis
por: Bakherad, Maryam, et al.
Publicado: (2021)

The Prognostic Role of LRIG Proteins in Endometrial Cancer
por: Razumova, Zoia, et al.
Publicado: (2021)

MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter
por: Álvaro-Blanco, Josué, et al.
Publicado: (2017)

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells
por: Giordani, Giorgia, et al.
Publicado: (2016)

ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
por: Adusumilli, Vijay S., et al.
Publicado: (2021)

Lrig1 Expression in Human Sebaceous Gland Tumors
por: Pünchera, Jöri, et al.
Publicado: (2016)

Gatekeepers of Knowledge
por: Zeegers, Margaret
Publicado: (2010)

Vertebrate Lrig3-ErbB Interactions Occur In Vitro but Are Unlikely to Play a Role in Lrig3-Dependent Inner Ear Morphogenesis
por: Abraira, Victoria E., et al.
Publicado: (2010)

A Myc–microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes
por: Polioudakis, Damon, et al.
Publicado: (2013)

Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA
por: Nakamura, Takahiro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_o5le604393hmf1mqn0b26idvq0