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Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence
Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX-2 are not yet fully understood. Here, we inves...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110573/ https://www.ncbi.nlm.nih.gov/pubmed/33972599 http://dx.doi.org/10.1038/s41598-021-89220-5 |