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Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors

Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and has demonstrated clinical activity in gastric/gastroesophagea...

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Detalles Bibliográficos
Autores principales:	Caldwell, Charles, Rottman, James B., Paces, Will, Bueche, Elizabeth, Reitsma, Sofia, Gibb, Joseph, Adisetiyo, Vitria, Haas, Michael S., Heath, Heidi, Newman, Walter, Baum, Jason, Gianani, Roberto, Kagey, Michael H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110580/ https://www.ncbi.nlm.nih.gov/pubmed/33972574 http://dx.doi.org/10.1038/s41598-021-89060-3

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