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Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning proces...

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Autores principales: Wirth, Alexander, Wolf, Bettina, Huang, Cheng-Kai, Glage, Silke, Hofer, Sebastian J., Bankstahl, Marion, Bär, Christian, Thum, Thomas, Kahl, Kai G., Sigrist, Stephan J., Madeo, Frank, Bankstahl, Jens P., Ponimaskin, Evgeni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110654/
https://www.ncbi.nlm.nih.gov/pubmed/33517527
http://dx.doi.org/10.1007/s11357-020-00310-0
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author Wirth, Alexander
Wolf, Bettina
Huang, Cheng-Kai
Glage, Silke
Hofer, Sebastian J.
Bankstahl, Marion
Bär, Christian
Thum, Thomas
Kahl, Kai G.
Sigrist, Stephan J.
Madeo, Frank
Bankstahl, Jens P.
Ponimaskin, Evgeni
author_facet Wirth, Alexander
Wolf, Bettina
Huang, Cheng-Kai
Glage, Silke
Hofer, Sebastian J.
Bankstahl, Marion
Bär, Christian
Thum, Thomas
Kahl, Kai G.
Sigrist, Stephan J.
Madeo, Frank
Bankstahl, Jens P.
Ponimaskin, Evgeni
author_sort Wirth, Alexander
collection PubMed
description Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-020-00310-0.
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spelling pubmed-81106542021-05-13 Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length Wirth, Alexander Wolf, Bettina Huang, Cheng-Kai Glage, Silke Hofer, Sebastian J. Bankstahl, Marion Bär, Christian Thum, Thomas Kahl, Kai G. Sigrist, Stephan J. Madeo, Frank Bankstahl, Jens P. Ponimaskin, Evgeni GeroScience Original Article Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-020-00310-0. Springer International Publishing 2021-01-31 /pmc/articles/PMC8110654/ /pubmed/33517527 http://dx.doi.org/10.1007/s11357-020-00310-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Wirth, Alexander
Wolf, Bettina
Huang, Cheng-Kai
Glage, Silke
Hofer, Sebastian J.
Bankstahl, Marion
Bär, Christian
Thum, Thomas
Kahl, Kai G.
Sigrist, Stephan J.
Madeo, Frank
Bankstahl, Jens P.
Ponimaskin, Evgeni
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title_full Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title_fullStr Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title_full_unstemmed Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title_short Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
title_sort novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110654/
https://www.ncbi.nlm.nih.gov/pubmed/33517527
http://dx.doi.org/10.1007/s11357-020-00310-0
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