A ride through the epigenetic landscape: aging reversal by reprogramming

Aging has become one of the fastest-growing research topics in biology. However, exactly how the aging process occurs remains unknown. Epigenetics plays a significant role, and several epigenetic interventions can modulate lifespan. This review will explore the interplay between epigenetics and agin...

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Detalles Bibliográficos
Autores principales: de Lima Camillo, Lucas Paulo, Quinlan, Robert B. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110674/
https://www.ncbi.nlm.nih.gov/pubmed/33825176
http://dx.doi.org/10.1007/s11357-021-00358-6
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author de Lima Camillo, Lucas Paulo
Quinlan, Robert B. A.
author_facet de Lima Camillo, Lucas Paulo
Quinlan, Robert B. A.
author_sort de Lima Camillo, Lucas Paulo
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description Aging has become one of the fastest-growing research topics in biology. However, exactly how the aging process occurs remains unknown. Epigenetics plays a significant role, and several epigenetic interventions can modulate lifespan. This review will explore the interplay between epigenetics and aging, and how epigenetic reprogramming can be harnessed for age reversal. In vivo partial reprogramming holds great promise as a possible therapy, but several limitations remain. Rejuvenation by reprogramming is a young but rapidly expanding subfield in the biology of aging.
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spelling pubmed-81106742021-05-13 A ride through the epigenetic landscape: aging reversal by reprogramming de Lima Camillo, Lucas Paulo Quinlan, Robert B. A. GeroScience Review Aging has become one of the fastest-growing research topics in biology. However, exactly how the aging process occurs remains unknown. Epigenetics plays a significant role, and several epigenetic interventions can modulate lifespan. This review will explore the interplay between epigenetics and aging, and how epigenetic reprogramming can be harnessed for age reversal. In vivo partial reprogramming holds great promise as a possible therapy, but several limitations remain. Rejuvenation by reprogramming is a young but rapidly expanding subfield in the biology of aging. Springer International Publishing 2021-04-06 /pmc/articles/PMC8110674/ /pubmed/33825176 http://dx.doi.org/10.1007/s11357-021-00358-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
de Lima Camillo, Lucas Paulo
Quinlan, Robert B. A.
A ride through the epigenetic landscape: aging reversal by reprogramming
title A ride through the epigenetic landscape: aging reversal by reprogramming
title_full A ride through the epigenetic landscape: aging reversal by reprogramming
title_fullStr A ride through the epigenetic landscape: aging reversal by reprogramming
title_full_unstemmed A ride through the epigenetic landscape: aging reversal by reprogramming
title_short A ride through the epigenetic landscape: aging reversal by reprogramming
title_sort ride through the epigenetic landscape: aging reversal by reprogramming
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110674/
https://www.ncbi.nlm.nih.gov/pubmed/33825176
http://dx.doi.org/10.1007/s11357-021-00358-6
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