Mutations as Levy flights

Data from a long time evolution experiment with Escherichia Coli and from a large study on copy number variations in subjects with European ancestry are analyzed in order to argue that mutations can be described as Levy flights in the mutation space. These Levy flights have at least two components:...

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Autores principales: Leon, Dario A., Gonzalez, Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110745/
https://www.ncbi.nlm.nih.gov/pubmed/33972566
http://dx.doi.org/10.1038/s41598-021-88012-1
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author Leon, Dario A.
Gonzalez, Augusto
author_facet Leon, Dario A.
Gonzalez, Augusto
author_sort Leon, Dario A.
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description Data from a long time evolution experiment with Escherichia Coli and from a large study on copy number variations in subjects with European ancestry are analyzed in order to argue that mutations can be described as Levy flights in the mutation space. These Levy flights have at least two components: random single-base substitutions and large DNA rearrangements. From the data, we get estimations for the time rates of both events and the size distribution function of large rearrangements.
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spelling pubmed-81107452021-05-12 Mutations as Levy flights Leon, Dario A. Gonzalez, Augusto Sci Rep Article Data from a long time evolution experiment with Escherichia Coli and from a large study on copy number variations in subjects with European ancestry are analyzed in order to argue that mutations can be described as Levy flights in the mutation space. These Levy flights have at least two components: random single-base substitutions and large DNA rearrangements. From the data, we get estimations for the time rates of both events and the size distribution function of large rearrangements. Nature Publishing Group UK 2021-05-10 /pmc/articles/PMC8110745/ /pubmed/33972566 http://dx.doi.org/10.1038/s41598-021-88012-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Leon, Dario A.
Gonzalez, Augusto
Mutations as Levy flights
title Mutations as Levy flights
title_full Mutations as Levy flights
title_fullStr Mutations as Levy flights
title_full_unstemmed Mutations as Levy flights
title_short Mutations as Levy flights
title_sort mutations as levy flights
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110745/
https://www.ncbi.nlm.nih.gov/pubmed/33972566
http://dx.doi.org/10.1038/s41598-021-88012-1
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