Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-shaping proteins regulate innate host defense remains largely unknown. Herein we show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through the maintena...

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Detalles Bibliográficos
Autores principales: Silwal, Prashanta, Kim, Jin Kyung, Jeon, Sang Min, Lee, June-Young, Kim, Young Jae, Kim, Yi Sak, Seo, Yeji, Kim, Jihye, Kim, Soo Yeon, Lee, Min Joung, Heo, Jun Young, Jung, Mi-Ja, Kim, Hyun Sik, Hyun, Dong-Wook, Han, Jeong Eun, Whang, Jake, Huh, Yang Hoon, Lee, Sang-Hee, Heo, Won Do, Kim, Jin-Man, Bae, Jin-Woo, Jo, Eun-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110749/
https://www.ncbi.nlm.nih.gov/pubmed/33972668
http://dx.doi.org/10.1038/s42003-021-02073-6

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