Emerging concepts in intestinal immune control of obesity-related metabolic disease

The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestina...

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Detalles Bibliográficos
Autores principales: Khan, Saad, Luck, Helen, Winer, Shawn, Winer, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110751/
https://www.ncbi.nlm.nih.gov/pubmed/33972511
http://dx.doi.org/10.1038/s41467-021-22727-7
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author Khan, Saad
Luck, Helen
Winer, Shawn
Winer, Daniel A.
author_facet Khan, Saad
Luck, Helen
Winer, Shawn
Winer, Daniel A.
author_sort Khan, Saad
collection PubMed
description The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.
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spelling pubmed-81107512021-05-14 Emerging concepts in intestinal immune control of obesity-related metabolic disease Khan, Saad Luck, Helen Winer, Shawn Winer, Daniel A. Nat Commun Review Article The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease. Nature Publishing Group UK 2021-05-10 /pmc/articles/PMC8110751/ /pubmed/33972511 http://dx.doi.org/10.1038/s41467-021-22727-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Khan, Saad
Luck, Helen
Winer, Shawn
Winer, Daniel A.
Emerging concepts in intestinal immune control of obesity-related metabolic disease
title Emerging concepts in intestinal immune control of obesity-related metabolic disease
title_full Emerging concepts in intestinal immune control of obesity-related metabolic disease
title_fullStr Emerging concepts in intestinal immune control of obesity-related metabolic disease
title_full_unstemmed Emerging concepts in intestinal immune control of obesity-related metabolic disease
title_short Emerging concepts in intestinal immune control of obesity-related metabolic disease
title_sort emerging concepts in intestinal immune control of obesity-related metabolic disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110751/
https://www.ncbi.nlm.nih.gov/pubmed/33972511
http://dx.doi.org/10.1038/s41467-021-22727-7
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