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Discontinuous epidemic transition due to limited testing

High impact epidemics constitute one of the largest threats humanity is facing in the 21(st) century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if t...

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Autores principales: Scarselli, Davide, Budanur, Nazmi Burak, Timme, Marc, Hof, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110767/
https://www.ncbi.nlm.nih.gov/pubmed/33972522
http://dx.doi.org/10.1038/s41467-021-22725-9
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author Scarselli, Davide
Budanur, Nazmi Burak
Timme, Marc
Hof, Björn
author_facet Scarselli, Davide
Budanur, Nazmi Burak
Timme, Marc
Hof, Björn
author_sort Scarselli, Davide
collection PubMed
description High impact epidemics constitute one of the largest threats humanity is facing in the 21(st) century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios.
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spelling pubmed-81107672021-05-14 Discontinuous epidemic transition due to limited testing Scarselli, Davide Budanur, Nazmi Burak Timme, Marc Hof, Björn Nat Commun Article High impact epidemics constitute one of the largest threats humanity is facing in the 21(st) century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios. Nature Publishing Group UK 2021-05-10 /pmc/articles/PMC8110767/ /pubmed/33972522 http://dx.doi.org/10.1038/s41467-021-22725-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Scarselli, Davide
Budanur, Nazmi Burak
Timme, Marc
Hof, Björn
Discontinuous epidemic transition due to limited testing
title Discontinuous epidemic transition due to limited testing
title_full Discontinuous epidemic transition due to limited testing
title_fullStr Discontinuous epidemic transition due to limited testing
title_full_unstemmed Discontinuous epidemic transition due to limited testing
title_short Discontinuous epidemic transition due to limited testing
title_sort discontinuous epidemic transition due to limited testing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110767/
https://www.ncbi.nlm.nih.gov/pubmed/33972522
http://dx.doi.org/10.1038/s41467-021-22725-9
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