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RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections formed during development which may contribute to symptoms of TSC, such as intellectual disabilities, autism, and epilepsy. Yet models examining the molecular basis for axonal guidance defects in developing h...

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Detalles Bibliográficos
Autores principales:	Catlett, Timothy S., Onesto, Massimo M., McCann, Alec J., Rempel, Sarah K., Glass, Jennifer, Franz, David N., Gómez, Timothy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110792/ https://www.ncbi.nlm.nih.gov/pubmed/33972524 http://dx.doi.org/10.1038/s41467-021-22770-4

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