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TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis

Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was assessed to monitor evolution of the TCR repertoire in...

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Detalles Bibliográficos
Autores principales:	Al Khabouri, Shaima, Benson, Robert A., Prendergast, Catriona T., Gray, Joshua I., Otto, Thomas D., Brewer, James M., Garside, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110912/ https://www.ncbi.nlm.nih.gov/pubmed/33986757 http://dx.doi.org/10.3389/fimmu.2021.669856

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