Roles of Toll-Like Receptor 3 in Human Tumors

Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Xin, Li, Song, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111175/
https://www.ncbi.nlm.nih.gov/pubmed/33986756
http://dx.doi.org/10.3389/fimmu.2021.667454
_version_ 1783690445524566016
author Zheng, Xin
Li, Song
Yang, Hui
author_facet Zheng, Xin
Li, Song
Yang, Hui
author_sort Zheng, Xin
collection PubMed
description Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3 has also been detected in some tumors. However TLR3 can play protumor or antitumor roles in different tumors or cell lines. Here, we review the basic signaling associated with TLR3 and the pro- or antitumor roles of TLR3 in different types of tumors and discuss the possible reasons for the opposing roles of TLR3 in tumors.
format Online
Article
Text
id pubmed-8111175
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81111752021-05-12 Roles of Toll-Like Receptor 3 in Human Tumors Zheng, Xin Li, Song Yang, Hui Front Immunol Immunology Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons. In addition to its immune-associated role, TLR3 has also been detected in some tumors. However TLR3 can play protumor or antitumor roles in different tumors or cell lines. Here, we review the basic signaling associated with TLR3 and the pro- or antitumor roles of TLR3 in different types of tumors and discuss the possible reasons for the opposing roles of TLR3 in tumors. Frontiers Media S.A. 2021-04-27 /pmc/articles/PMC8111175/ /pubmed/33986756 http://dx.doi.org/10.3389/fimmu.2021.667454 Text en Copyright © 2021 Zheng, Li and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Xin
Li, Song
Yang, Hui
Roles of Toll-Like Receptor 3 in Human Tumors
title Roles of Toll-Like Receptor 3 in Human Tumors
title_full Roles of Toll-Like Receptor 3 in Human Tumors
title_fullStr Roles of Toll-Like Receptor 3 in Human Tumors
title_full_unstemmed Roles of Toll-Like Receptor 3 in Human Tumors
title_short Roles of Toll-Like Receptor 3 in Human Tumors
title_sort roles of toll-like receptor 3 in human tumors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111175/
https://www.ncbi.nlm.nih.gov/pubmed/33986756
http://dx.doi.org/10.3389/fimmu.2021.667454
work_keys_str_mv AT zhengxin rolesoftolllikereceptor3inhumantumors
AT lisong rolesoftolllikereceptor3inhumantumors
AT yanghui rolesoftolllikereceptor3inhumantumors

Ejemplares similares