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Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation
Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription and translation processes. The post-transcriptional control of mRNA metabolism is mediated by the so-called RNA-bind...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111222/ https://www.ncbi.nlm.nih.gov/pubmed/33987205 http://dx.doi.org/10.3389/fmolb.2021.658852 |
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author | Velázquez-Cruz, Alejandro Baños-Jaime, Blanca Díaz-Quintana, Antonio De la Rosa, Miguel A. Díaz-Moreno, Irene |
author_facet | Velázquez-Cruz, Alejandro Baños-Jaime, Blanca Díaz-Quintana, Antonio De la Rosa, Miguel A. Díaz-Moreno, Irene |
author_sort | Velázquez-Cruz, Alejandro |
collection | PubMed |
description | Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription and translation processes. The post-transcriptional control of mRNA metabolism is mediated by the so-called RNA-binding proteins (RBPs), which assemble with specific transcripts forming messenger ribonucleoprotein particles of highly dynamic composition. RBPs constitute a class of trans-acting regulatory proteins with affinity for certain consensus elements present in mRNA molecules. However, these regulators are subjected to post-translational modifications (PTMs) that constantly adjust their activity to maintain cell homeostasis. PTMs can dramatically change the subcellular localization, the binding affinity for RNA and protein partners, and the turnover rate of RBPs. Moreover, the ability of many RBPs to undergo phase transition and/or their recruitment to previously formed membrane-less organelles, such as stress granules, is also regulated by specific PTMs. Interestingly, the dysregulation of PTMs in RBPs has been associated with the pathophysiology of many different diseases. Abnormal PTM patterns can lead to the distortion of the physiological role of RBPs due to mislocalization, loss or gain of function, and/or accelerated or disrupted degradation. This Mini Review offers a broad overview of the post-translational regulation of selected RBPs and the involvement of their dysregulation in neurodegenerative disorders, cancer and other pathologies. |
format | Online Article Text |
id | pubmed-8111222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81112222021-05-12 Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation Velázquez-Cruz, Alejandro Baños-Jaime, Blanca Díaz-Quintana, Antonio De la Rosa, Miguel A. Díaz-Moreno, Irene Front Mol Biosci Molecular Biosciences Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription and translation processes. The post-transcriptional control of mRNA metabolism is mediated by the so-called RNA-binding proteins (RBPs), which assemble with specific transcripts forming messenger ribonucleoprotein particles of highly dynamic composition. RBPs constitute a class of trans-acting regulatory proteins with affinity for certain consensus elements present in mRNA molecules. However, these regulators are subjected to post-translational modifications (PTMs) that constantly adjust their activity to maintain cell homeostasis. PTMs can dramatically change the subcellular localization, the binding affinity for RNA and protein partners, and the turnover rate of RBPs. Moreover, the ability of many RBPs to undergo phase transition and/or their recruitment to previously formed membrane-less organelles, such as stress granules, is also regulated by specific PTMs. Interestingly, the dysregulation of PTMs in RBPs has been associated with the pathophysiology of many different diseases. Abnormal PTM patterns can lead to the distortion of the physiological role of RBPs due to mislocalization, loss or gain of function, and/or accelerated or disrupted degradation. This Mini Review offers a broad overview of the post-translational regulation of selected RBPs and the involvement of their dysregulation in neurodegenerative disorders, cancer and other pathologies. Frontiers Media S.A. 2021-04-27 /pmc/articles/PMC8111222/ /pubmed/33987205 http://dx.doi.org/10.3389/fmolb.2021.658852 Text en Copyright © 2021 Velázquez-Cruz, Baños-Jaime, Díaz-Quintana, De la Rosa and Díaz-Moreno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Velázquez-Cruz, Alejandro Baños-Jaime, Blanca Díaz-Quintana, Antonio De la Rosa, Miguel A. Díaz-Moreno, Irene Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title | Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title_full | Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title_fullStr | Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title_full_unstemmed | Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title_short | Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation |
title_sort | post-translational control of rna-binding proteins and disease-related dysregulation |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111222/ https://www.ncbi.nlm.nih.gov/pubmed/33987205 http://dx.doi.org/10.3389/fmolb.2021.658852 |
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