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Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?

The success of immunotherapy that targets inhibitory T cell receptors for the treatment of multiple cancers has seen the anti-tumor immune response re-emerge as a promising biomarker of response to therapy. Longitudinal characterization of T cells in the tumor microenvironment (TME) helps us underst...

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Autores principales: Principe, Nicola, Kidman, Joel, Lake, Richard A., Lesterhuis, Willem Joost, Nowak, Anna K., McDonnell, Alison M., Chee, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111299/
https://www.ncbi.nlm.nih.gov/pubmed/33987104
http://dx.doi.org/10.3389/fonc.2021.672747
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author Principe, Nicola
Kidman, Joel
Lake, Richard A.
Lesterhuis, Willem Joost
Nowak, Anna K.
McDonnell, Alison M.
Chee, Jonathan
author_facet Principe, Nicola
Kidman, Joel
Lake, Richard A.
Lesterhuis, Willem Joost
Nowak, Anna K.
McDonnell, Alison M.
Chee, Jonathan
author_sort Principe, Nicola
collection PubMed
description The success of immunotherapy that targets inhibitory T cell receptors for the treatment of multiple cancers has seen the anti-tumor immune response re-emerge as a promising biomarker of response to therapy. Longitudinal characterization of T cells in the tumor microenvironment (TME) helps us understand how to promote effective anti-tumor immunity. However, serial analyses at the tumor site are rarely feasible in clinical practice. Malignant pleural effusions (MPE) associated with thoracic cancers are an abnormal accumulation of fluid in the pleural space that is routinely drained for patient symptom control. This fluid contains tumor cells and immune cells, including lymphocytes, macrophages and dendritic cells, providing a window into the local tumor microenvironment. Recurrent MPE is common, and provides an opportunity for longitudinal analysis of the tumor site in a clinical setting. Here, we review the phenotype of MPE-derived T cells, comparing them to tumor and blood T cells. We discuss the benefits and limitations of their use as potential dynamic biomarkers of response to therapy.
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spelling pubmed-81112992021-05-12 Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity? Principe, Nicola Kidman, Joel Lake, Richard A. Lesterhuis, Willem Joost Nowak, Anna K. McDonnell, Alison M. Chee, Jonathan Front Oncol Oncology The success of immunotherapy that targets inhibitory T cell receptors for the treatment of multiple cancers has seen the anti-tumor immune response re-emerge as a promising biomarker of response to therapy. Longitudinal characterization of T cells in the tumor microenvironment (TME) helps us understand how to promote effective anti-tumor immunity. However, serial analyses at the tumor site are rarely feasible in clinical practice. Malignant pleural effusions (MPE) associated with thoracic cancers are an abnormal accumulation of fluid in the pleural space that is routinely drained for patient symptom control. This fluid contains tumor cells and immune cells, including lymphocytes, macrophages and dendritic cells, providing a window into the local tumor microenvironment. Recurrent MPE is common, and provides an opportunity for longitudinal analysis of the tumor site in a clinical setting. Here, we review the phenotype of MPE-derived T cells, comparing them to tumor and blood T cells. We discuss the benefits and limitations of their use as potential dynamic biomarkers of response to therapy. Frontiers Media S.A. 2021-04-27 /pmc/articles/PMC8111299/ /pubmed/33987104 http://dx.doi.org/10.3389/fonc.2021.672747 Text en Copyright © 2021 Principe, Kidman, Lake, Lesterhuis, Nowak, McDonnell and Chee https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Principe, Nicola
Kidman, Joel
Lake, Richard A.
Lesterhuis, Willem Joost
Nowak, Anna K.
McDonnell, Alison M.
Chee, Jonathan
Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title_full Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title_fullStr Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title_full_unstemmed Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title_short Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
title_sort malignant pleural effusions—a window into local anti-tumor t cell immunity?
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111299/
https://www.ncbi.nlm.nih.gov/pubmed/33987104
http://dx.doi.org/10.3389/fonc.2021.672747
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