Cargando…
Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis
Differentiated thyroid cancer (DTC) represents the most common form of thyroid neoplasms and is becoming increasingly prevalent. Evidence suggests a possible relationship between DTC diagnosis and subsequent atrial fibrillation (AF). If confirmed, this may present an alarming health risk (AF) in an...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111325/ https://www.ncbi.nlm.nih.gov/pubmed/33794503 http://dx.doi.org/10.1530/ERC-20-0496 |
_version_ | 1783690476497403904 |
---|---|
author | Kostopoulos, Georgios Doundoulakis, Ioannis Antza, Christina Bouras, Emmanouil Nirantharakumar, Krishnarajah Tsiachris, Dimitrios Thomas, G Neil Lip, Gregory Y H Toulis, Konstantinos A |
author_facet | Kostopoulos, Georgios Doundoulakis, Ioannis Antza, Christina Bouras, Emmanouil Nirantharakumar, Krishnarajah Tsiachris, Dimitrios Thomas, G Neil Lip, Gregory Y H Toulis, Konstantinos A |
author_sort | Kostopoulos, Georgios |
collection | PubMed |
description | Differentiated thyroid cancer (DTC) represents the most common form of thyroid neoplasms and is becoming increasingly prevalent. Evidence suggests a possible relationship between DTC diagnosis and subsequent atrial fibrillation (AF). If confirmed, this may present an alarming health risk (AF) in an otherwise condition with a relatively good prognosis (DTC). The aim of this systematic review and meta-analysis is to provide for the first time a pooled estimate of AF incidence in DTC patients in comparison to healthy controls. A detailed search in electronic databases, clinical trial registries and grey literature was performed to identify studies reporting the incidence of AF in DTC patients. Newcastle–Ottawa quality assessment scale was used to assess study quality. We used a random effects (RE) generalized linear mixed model (GLMM) in pooling of individual studies and also calculated a prediction interval for the estimate of a new study. Six observational studies met the eligibility criteria, which included totally 187,754 patients with DTC and 199,770 healthy controls. The median follow-up period was 4.3 to 18.8 years; the incidence rate of AF was 4.86 (95% CI, 3.29 to 7.17, I(2) = 96%) cases per 1000 person-years, while the incidence rate ratio was 1.54 (95% CI, 1.44 to 1.65, I(2) = 0%, 95% PI, 1.33 to 1.78).This is the first meta-analysis to confirm that patients with DTC are at a high risk for developing AF, which may be attributed to a state of iatrogenic hyperthyroidism due to long-term thyrotropin suppression therapy. |
format | Online Article Text |
id | pubmed-8111325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81113252021-05-13 Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis Kostopoulos, Georgios Doundoulakis, Ioannis Antza, Christina Bouras, Emmanouil Nirantharakumar, Krishnarajah Tsiachris, Dimitrios Thomas, G Neil Lip, Gregory Y H Toulis, Konstantinos A Endocr Relat Cancer Research Differentiated thyroid cancer (DTC) represents the most common form of thyroid neoplasms and is becoming increasingly prevalent. Evidence suggests a possible relationship between DTC diagnosis and subsequent atrial fibrillation (AF). If confirmed, this may present an alarming health risk (AF) in an otherwise condition with a relatively good prognosis (DTC). The aim of this systematic review and meta-analysis is to provide for the first time a pooled estimate of AF incidence in DTC patients in comparison to healthy controls. A detailed search in electronic databases, clinical trial registries and grey literature was performed to identify studies reporting the incidence of AF in DTC patients. Newcastle–Ottawa quality assessment scale was used to assess study quality. We used a random effects (RE) generalized linear mixed model (GLMM) in pooling of individual studies and also calculated a prediction interval for the estimate of a new study. Six observational studies met the eligibility criteria, which included totally 187,754 patients with DTC and 199,770 healthy controls. The median follow-up period was 4.3 to 18.8 years; the incidence rate of AF was 4.86 (95% CI, 3.29 to 7.17, I(2) = 96%) cases per 1000 person-years, while the incidence rate ratio was 1.54 (95% CI, 1.44 to 1.65, I(2) = 0%, 95% PI, 1.33 to 1.78).This is the first meta-analysis to confirm that patients with DTC are at a high risk for developing AF, which may be attributed to a state of iatrogenic hyperthyroidism due to long-term thyrotropin suppression therapy. Bioscientifica Ltd 2021-03-31 /pmc/articles/PMC8111325/ /pubmed/33794503 http://dx.doi.org/10.1530/ERC-20-0496 Text en © 2021 Society for Endocrinology https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Kostopoulos, Georgios Doundoulakis, Ioannis Antza, Christina Bouras, Emmanouil Nirantharakumar, Krishnarajah Tsiachris, Dimitrios Thomas, G Neil Lip, Gregory Y H Toulis, Konstantinos A Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title | Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title_full | Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title_fullStr | Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title_full_unstemmed | Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title_short | Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
title_sort | incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111325/ https://www.ncbi.nlm.nih.gov/pubmed/33794503 http://dx.doi.org/10.1530/ERC-20-0496 |
work_keys_str_mv | AT kostopoulosgeorgios incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT doundoulakisioannis incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT antzachristina incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT bourasemmanouil incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT nirantharakumarkrishnarajah incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT tsiachrisdimitrios incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT thomasgneil incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT lipgregoryyh incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis AT touliskonstantinosa incidentatrialfibrillationinpatientswithdifferentiatedthyroidcancerametaanalysis |