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High-magnesium exposure to bullfrog heart causes ST segment elevation
Hypermagnesemia occurs in elderly people or patients with renal insufficiency after excessive ingestion of magnesium-containing laxatives. In addition to typical electrocardiogram (ECG) findings caused by conduction defects, changes in the ST segments and T waves are also observed in patients with s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111350/ https://www.ncbi.nlm.nih.gov/pubmed/33612659 http://dx.doi.org/10.1292/jvms.20-0720 |
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author | KAZAMA, Itsuro |
author_facet | KAZAMA, Itsuro |
author_sort | KAZAMA, Itsuro |
collection | PubMed |
description | Hypermagnesemia occurs in elderly people or patients with renal insufficiency after excessive ingestion of magnesium-containing laxatives. In addition to typical electrocardiogram (ECG) findings caused by conduction defects, changes in the ST segments and T waves are also observed in patients with severe hypermagnesemia. This suggested the involvement of similar pathophysiology to acute myocardial infarction, as we previously demonstrated using burn-induced subepicardial injury model in frog hearts. In the present study, by exposing the bullfrog heart to high-magnesium solution, we reproduced prominent ST segment changes in ECG as actually observed in patients with severe hypermagnesemia. In addition to the great increase in the T waves, the ECG showed a marked elevation of the ST segments and the cardiac action potential demonstrated a marked shift of the resting membrane potential to the depolarized side. High-magnesium exposure did not affect the abundance of Na(+)/K(+)-ATPase proteins. However, the pharmacological stimulation of Na(+)/K(+)-ATPase activity by insulin quickly retrieved the elevated ST segments in ECG. From these results, the functional blockade of Na(+)/K(+)-ATPase activity by magnesium ions was thought to be responsible for generating the potassium concentration gradient and the subsequent ST segment changes. |
format | Online Article Text |
id | pubmed-8111350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81113502021-05-13 High-magnesium exposure to bullfrog heart causes ST segment elevation KAZAMA, Itsuro J Vet Med Sci Physiology Hypermagnesemia occurs in elderly people or patients with renal insufficiency after excessive ingestion of magnesium-containing laxatives. In addition to typical electrocardiogram (ECG) findings caused by conduction defects, changes in the ST segments and T waves are also observed in patients with severe hypermagnesemia. This suggested the involvement of similar pathophysiology to acute myocardial infarction, as we previously demonstrated using burn-induced subepicardial injury model in frog hearts. In the present study, by exposing the bullfrog heart to high-magnesium solution, we reproduced prominent ST segment changes in ECG as actually observed in patients with severe hypermagnesemia. In addition to the great increase in the T waves, the ECG showed a marked elevation of the ST segments and the cardiac action potential demonstrated a marked shift of the resting membrane potential to the depolarized side. High-magnesium exposure did not affect the abundance of Na(+)/K(+)-ATPase proteins. However, the pharmacological stimulation of Na(+)/K(+)-ATPase activity by insulin quickly retrieved the elevated ST segments in ECG. From these results, the functional blockade of Na(+)/K(+)-ATPase activity by magnesium ions was thought to be responsible for generating the potassium concentration gradient and the subsequent ST segment changes. The Japanese Society of Veterinary Science 2021-02-22 2021-04 /pmc/articles/PMC8111350/ /pubmed/33612659 http://dx.doi.org/10.1292/jvms.20-0720 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Physiology KAZAMA, Itsuro High-magnesium exposure to bullfrog heart causes ST segment elevation |
title | High-magnesium exposure to bullfrog heart causes ST segment
elevation |
title_full | High-magnesium exposure to bullfrog heart causes ST segment
elevation |
title_fullStr | High-magnesium exposure to bullfrog heart causes ST segment
elevation |
title_full_unstemmed | High-magnesium exposure to bullfrog heart causes ST segment
elevation |
title_short | High-magnesium exposure to bullfrog heart causes ST segment
elevation |
title_sort | high-magnesium exposure to bullfrog heart causes st segment
elevation |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111350/ https://www.ncbi.nlm.nih.gov/pubmed/33612659 http://dx.doi.org/10.1292/jvms.20-0720 |
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