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Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis)
Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111363/ https://www.ncbi.nlm.nih.gov/pubmed/33692223 http://dx.doi.org/10.1292/jvms.20-0606 |
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author | PAI, Chungyu NAKAYAMA, Shunya ITO-FUJISHIRO, Yasuyo KANAYAMA, Kiichi MUNESUE, Yoshiko SANKAI, Tadashi YASUTOMI, Yasuhiro KOIE, Hiroshi AGEYAMA, Naohide |
author_facet | PAI, Chungyu NAKAYAMA, Shunya ITO-FUJISHIRO, Yasuyo KANAYAMA, Kiichi MUNESUE, Yoshiko SANKAI, Tadashi YASUTOMI, Yasuhiro KOIE, Hiroshi AGEYAMA, Naohide |
author_sort | PAI, Chungyu |
collection | PubMed |
description | Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as indicators for the diagnosis of human heart failure. However, no reference values for ANP and BNP have been reported for heart disease in nonhuman primates. In this study, we recorded the age, sex, and body weight of 202 cynomolgus monkeys, and performed evaluations to assess the ANP and BNP levels, electrocardiography and echocardiography, and accordingly divided the monkeys into two groups: healthy monkeys and those with spontaneous cardiac disease. Statistical analysis was performed to determine the relationship of ANP and BNP with the factors of age, sex, and body weight. No significant relationship was found between the levels of ANP and BNP and the factors of age, sex, and body weight. However, both the ANP and BNP levels were significantly different between the healthy monkeys and monkeys with valvular disease. Similar to humans, the ANP and BNP levels tended to increase with the progression of cardiac disease in monkeys. Based on these results, we concluded that ANP and BNP are indicators of cardiac disease in nonhuman primates, and that this nonhuman primate cardiac disease model is applicable for cardiology research in humans. |
format | Online Article Text |
id | pubmed-8111363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81113632021-05-13 Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis) PAI, Chungyu NAKAYAMA, Shunya ITO-FUJISHIRO, Yasuyo KANAYAMA, Kiichi MUNESUE, Yoshiko SANKAI, Tadashi YASUTOMI, Yasuhiro KOIE, Hiroshi AGEYAMA, Naohide J Vet Med Sci Laboratory Animal Science Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as indicators for the diagnosis of human heart failure. However, no reference values for ANP and BNP have been reported for heart disease in nonhuman primates. In this study, we recorded the age, sex, and body weight of 202 cynomolgus monkeys, and performed evaluations to assess the ANP and BNP levels, electrocardiography and echocardiography, and accordingly divided the monkeys into two groups: healthy monkeys and those with spontaneous cardiac disease. Statistical analysis was performed to determine the relationship of ANP and BNP with the factors of age, sex, and body weight. No significant relationship was found between the levels of ANP and BNP and the factors of age, sex, and body weight. However, both the ANP and BNP levels were significantly different between the healthy monkeys and monkeys with valvular disease. Similar to humans, the ANP and BNP levels tended to increase with the progression of cardiac disease in monkeys. Based on these results, we concluded that ANP and BNP are indicators of cardiac disease in nonhuman primates, and that this nonhuman primate cardiac disease model is applicable for cardiology research in humans. The Japanese Society of Veterinary Science 2021-03-09 2021-04 /pmc/articles/PMC8111363/ /pubmed/33692223 http://dx.doi.org/10.1292/jvms.20-0606 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Laboratory Animal Science PAI, Chungyu NAKAYAMA, Shunya ITO-FUJISHIRO, Yasuyo KANAYAMA, Kiichi MUNESUE, Yoshiko SANKAI, Tadashi YASUTOMI, Yasuhiro KOIE, Hiroshi AGEYAMA, Naohide Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis) |
title | Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (Macaca fascicularis) |
title_full | Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (Macaca fascicularis) |
title_fullStr | Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (Macaca fascicularis) |
title_full_unstemmed | Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (Macaca fascicularis) |
title_short | Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (Macaca fascicularis) |
title_sort | usefulness of cardiac hormones for evaluating valvular disease in cynomolgus
monkeys (macaca fascicularis) |
topic | Laboratory Animal Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111363/ https://www.ncbi.nlm.nih.gov/pubmed/33692223 http://dx.doi.org/10.1292/jvms.20-0606 |
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