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Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model

Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their impo...

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Detalles Bibliográficos
Autores principales: Kao, Ta-Chu, Sadabadi, Mahdieh S., Hennequin, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111422/
https://www.ncbi.nlm.nih.gov/pubmed/33789082
http://dx.doi.org/10.1016/j.neuron.2021.03.009
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author Kao, Ta-Chu
Sadabadi, Mahdieh S.
Hennequin, Guillaume
author_facet Kao, Ta-Chu
Sadabadi, Mahdieh S.
Hennequin, Guillaume
author_sort Kao, Ta-Chu
collection PubMed
description Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their importance raises questions regarding how they are, or ought to be, set. Here, we formulate motor preparation as optimal anticipatory control of future movements and show that the solution requires a form of internal feedback control of cortical circuit dynamics. In contrast to a simple feedforward strategy, feedback control enables fast movement preparation by selectively controlling the cortical state in the small subspace that matters for the upcoming movement. Feedback but not feedforward control explains the orthogonality between preparatory and movement activity observed in reaching monkeys. We propose a circuit model in which optimal preparatory control is implemented as a thalamo-cortical loop gated by the basal ganglia.
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spelling pubmed-81114222021-05-14 Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model Kao, Ta-Chu Sadabadi, Mahdieh S. Hennequin, Guillaume Neuron Article Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their importance raises questions regarding how they are, or ought to be, set. Here, we formulate motor preparation as optimal anticipatory control of future movements and show that the solution requires a form of internal feedback control of cortical circuit dynamics. In contrast to a simple feedforward strategy, feedback control enables fast movement preparation by selectively controlling the cortical state in the small subspace that matters for the upcoming movement. Feedback but not feedforward control explains the orthogonality between preparatory and movement activity observed in reaching monkeys. We propose a circuit model in which optimal preparatory control is implemented as a thalamo-cortical loop gated by the basal ganglia. Cell Press 2021-05-05 /pmc/articles/PMC8111422/ /pubmed/33789082 http://dx.doi.org/10.1016/j.neuron.2021.03.009 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kao, Ta-Chu
Sadabadi, Mahdieh S.
Hennequin, Guillaume
Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title_full Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title_fullStr Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title_full_unstemmed Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title_short Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
title_sort optimal anticipatory control as a theory of motor preparation: a thalamo-cortical circuit model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111422/
https://www.ncbi.nlm.nih.gov/pubmed/33789082
http://dx.doi.org/10.1016/j.neuron.2021.03.009
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