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Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their impo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111422/ https://www.ncbi.nlm.nih.gov/pubmed/33789082 http://dx.doi.org/10.1016/j.neuron.2021.03.009 |
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author | Kao, Ta-Chu Sadabadi, Mahdieh S. Hennequin, Guillaume |
author_facet | Kao, Ta-Chu Sadabadi, Mahdieh S. Hennequin, Guillaume |
author_sort | Kao, Ta-Chu |
collection | PubMed |
description | Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their importance raises questions regarding how they are, or ought to be, set. Here, we formulate motor preparation as optimal anticipatory control of future movements and show that the solution requires a form of internal feedback control of cortical circuit dynamics. In contrast to a simple feedforward strategy, feedback control enables fast movement preparation by selectively controlling the cortical state in the small subspace that matters for the upcoming movement. Feedback but not feedforward control explains the orthogonality between preparatory and movement activity observed in reaching monkeys. We propose a circuit model in which optimal preparatory control is implemented as a thalamo-cortical loop gated by the basal ganglia. |
format | Online Article Text |
id | pubmed-8111422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-81114222021-05-14 Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model Kao, Ta-Chu Sadabadi, Mahdieh S. Hennequin, Guillaume Neuron Article Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These “preparatory states” largely determine the subsequent evolution of both neural activity and behavior, and their importance raises questions regarding how they are, or ought to be, set. Here, we formulate motor preparation as optimal anticipatory control of future movements and show that the solution requires a form of internal feedback control of cortical circuit dynamics. In contrast to a simple feedforward strategy, feedback control enables fast movement preparation by selectively controlling the cortical state in the small subspace that matters for the upcoming movement. Feedback but not feedforward control explains the orthogonality between preparatory and movement activity observed in reaching monkeys. We propose a circuit model in which optimal preparatory control is implemented as a thalamo-cortical loop gated by the basal ganglia. Cell Press 2021-05-05 /pmc/articles/PMC8111422/ /pubmed/33789082 http://dx.doi.org/10.1016/j.neuron.2021.03.009 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kao, Ta-Chu Sadabadi, Mahdieh S. Hennequin, Guillaume Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title | Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title_full | Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title_fullStr | Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title_full_unstemmed | Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title_short | Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model |
title_sort | optimal anticipatory control as a theory of motor preparation: a thalamo-cortical circuit model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111422/ https://www.ncbi.nlm.nih.gov/pubmed/33789082 http://dx.doi.org/10.1016/j.neuron.2021.03.009 |
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