SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer

SH-1028 is an irreversible third-generation EGFR TKI. Both SH-1028 and osimertinib have a pyrimidine structure (a typical mutant-selective EGFR TKI structure). Compared with osimertinib, SH-1028 is modified on the indole ring, thus resulting in a more stable 6,7,8,9-tetrahydro-pyrrolo [1, 2-a] indol...

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Detalles Bibliográficos
Autores principales: Han, Luwei, Zhang, Xiaomeng, Wang, Zhiqiang, Zhang, Xian, Zhao, Liwen, Fu, Wei, Liang, Xiaobo, Zhang, Zhibo, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111447/
https://www.ncbi.nlm.nih.gov/pubmed/33986687
http://dx.doi.org/10.3389/fphar.2021.665253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111447/
https://www.ncbi.nlm.nih.gov/pubmed/33986687
http://dx.doi.org/10.3389/fphar.2021.665253

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