Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain

Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation of TLR4, localized to enlarged, cholesterol-enriched lipid rafts, designated here as inflammarafts. Conditional deletion of cholesterol transporters A...

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Detalles Bibliográficos
Autores principales: Navia-Pelaez, Juliana M., Choi, Soo-Ho, dos Santos Aggum Capettini, Luciano, Xia, Yining, Gonen, Ayelet, Agatisa-Boyle, Colin, Delay, Lauriane, Gonçalves dos Santos, Gilson, Catroli, Glaucilene F., Kim, Jungsu, Lu, Jenny W., Saylor, Benjamin, Winkels, Holger, Durant, Christopher P., Ghosheh, Yanal, Beaton, Graham, Ley, Klaus, Kufareva, Irina, Corr, Maripat, Yaksh, Tony L., Miller, Yury I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111462/
https://www.ncbi.nlm.nih.gov/pubmed/33970188
http://dx.doi.org/10.1084/jem.20202059

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